Synthetic peptide toxins
See the related productsSynthetic peptide toxins ideal for studying ion channels
Venoms issued from spiders, snakes, mollusks... contain potent toxins enabling the characterization of a large number of ion channels. These peptide toxins are very hard to obtain directly from animals and quantities obtained are not enough for providing research labs.
tebu-bio provides synthetic toxins with the ideal tools to study ion channels, which are becoming an important therapeutic target for drug discovery.
Key characteristics
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Broadest selection of highly innovative toxins (not found elsewhere)
- Originate from snakes, spiders, cone snails, scorpions, lizards...
- <70 amino acids
- Peptide sequence and folding guaranteed
- High purity (HPLC)
- Quality control by mass spectrometry
- Custom synthesis and modifications upon request
Order your toxins online here!
Ion channels and their targeted venomous toxins
Potential cation channel
- Vanillotoxin 3: selective ligand of TRPV1 channel
Sodium channel
- Protoxin II: selective inhibitor of Nav1.7
- Jingzhaotoxin-III: selective inhibitor of Nav1.5 channels
- Protoxin II-biotin: customized Protoxin II to perform new studies
- Hainantoxin-IV: potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs)
- Huwentoxin IV: lethal neurotoxin selectively acting on tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with an IC50 of 30 nM in rat DRG neurons.
- Huwentoxin I: selective inhibitor of N-type calcium channels, and TTXs channels
- μ-Conotoxin PIIIA: binding inhibitor of site 1 of voltage-gated sodium channels
- GsAF-I: voltage-gated sodium channel blocker
- GsAF-II: voltage-gated sodium channel blocker
- Phrixotoxin-3 (PaurTx3 or Beta-theraphotoxin-Ps1a): VGSC blocker
- Mu-conotoxin GIIIB : blocks Na-1.4 voltage-dependent sodium channels, which are predominantly expressed in muscle
Potassium channel
- Iberiotoxin: selective inhibitor of Maxi-K channel
- Charybdotoxin: blocker of voltage gated and Ca2+ activated K+ channels
- Leiurotoxin 1: Modulator of SK channels (small conductance Ca2+-activated K+ channels)
- Tamapin: Modulator of small conductance Ca2+-activated K+ channels (SK channels)
- Guangxitoxin 1E: inhibitor of Kv2.1 with an IC50 value of 1 nM and Kv2.2 with an IC50 value of 3 nM.
- ShK: voltage-dependent potassium channels inhibitor
- Margatoxin: Kv1.3 inhibitor
- HsTx1
- Apamin
- Tertiapin-Q
- ADWX-1: inhibitor of Kv1.3 channel with an IC50 of 1.89 pM
- Phrixotoxin-2 : specifically blocks recombinant Kv4.2 and Kv4.3 potassium channels
Calcium channel
- ω-agatoxin IVA: blocks specifically P/Q-type calcium channel
- ω-conotoxin GVIA: blocks specifically Cav2.2 channel
- ω-conotoxin MVIIC isolated from the venom of the cone Conus magus
- Protoxin II: inhibits voltage-gated calcium and sodium channel
- SNX482: modulator of the R-type current associated with the class α1E calcium channel (Cav2.3 from the CACNA1E gene)
- Maurocalcine: acting on ryanodine receptors with an affinity in the 10 nM range.
- Huwentoxin I
- ω Conotoxin SO-3
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ω-Conotoxin MVIIA
Chloride channel
- GaTx1: CFTR blocker
- GaTx2: is the most potent peptide inhibitor of ClC-2 chloride channel ever described.
- Chlorotoxin: binds to Cl- channels (small conductance epithelial chloride channels)
Acetylcholine receptor
- Waglerin 1: selective antagonist of muscle nicotinic acetylcholine receptors
- α-Conotoxin MI: acting on postsynaptic membranes. It binds onto and blocks nicotinic acetylcholine receptors (nAChR).
- α-Conotoxin GI: acting on postsynaptic membranes, which bind to the nicotinic acetylcholine receptor (nAChR).
- α-Conotoxin IMI: acting on postsynaptic membranes, and inhibitors of nicotinic acetylcholine receptors (nAChR)
- alpha-conotoxin GID: selectively blocks neuronal nicotinic acetylcholine receptors
NMDA
- Conantokin G: selective inhibitor of NR2B sub units of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons.
ASIC channel
- APETx2: selective blocker of the H(+)-gated sodium channel ASIC3 (ACCN3). The blockage is rapid and reversible
- Psalmotoxin 1 (PcTx1): ASIC1 channel selective blocker
Purinergic
- Purotoxin 1: the only one selective inhibitor of P2X3 receptor channel
Others
- Morphiceptin: the most selective agonist of µ-opoid receptors
- Lys-conopressin G: vasopressin-like peptide.
- GsMTx4: This toxin blocks mechanosensitive ion channels (strech-activated channels SAC).
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