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Histone peptides building blocks


We offer acetylated, mono-methylated, di-methylated and tri-methylated Lysine for the synthesis of histone peptides. The use of these building blocks, although not limited to making synthetic histone peptides, provides additional tools for researchers to help unravel the “histone code.”5

The lysine-rich amino terminal tail of the core histones undergo posttranslational modifications such as acetylation and methylation.1-2 Addition of acetyl group or 1 to 3 methyl groups occur at position specific lysines.3-4 These modifications, as well as phosphorylation of serine residues and others, serve to differentially regulate chromatin activity.5

Acetylated Lysines

Product

Size

Catalog nr

Fmoc-Lys(Ac)-OH
N-α-Fmoc-N-ε-acetyl-L-lysine, CAS# 159766-56-0

1 g

22502

5 g

23356

Boc-Lys(Ac)-OH
N-α-t-Boc-N-ε-acetyl-L-lysine, CAS# 6404-26-8

1 g

23084

5 g

23085

Methylated Lysines

Product

Size

Catalog nr

Fmoc-Lys(Me, Boc)-OH NEW
N-α-Fmoc-N-ε,ε-t-Boc-methyl-L-lysine

0.25 g

60327-025

1 g

60327-1

5 g

60327-5

Fmoc-Lys(Me)2-OH • HCl
Fmoc-Nε,ε-dimethyl-L-lysine hydrochloride salt CAS# 252049-10-8

250 mg

28211

1 g

28212

Boc-Lys(Me)2-OH
Boc-Nε,ε-dimethyl-L-lysine

250 mg

60025-025

1 g

60025-1

Fmoc-Lys(Me)3-OH chloride NEW
N-α-Fmoc-N-ε;ε;ε-trimethyl-L-lysine chloride

1 g

60260-1

 

Phosphorylated

Product

Size

Catalog nr

Fmoc-Ser[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L-phosphoserine, CAS# 158171-14-3

1 g

20419

5 g

20420

Fmoc-D-Ser[PO(OBzl)-OH]-OH NEW
N-α-Fmoc-O-benzyl-D-phosphoserine

1 g

60083-1

5 g

60083-5

Fmoc-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-L-phosphothreonine, CAS# 175291-56-2

1 g

20835

5 g

20836

Fmoc-D-Thr[PO(OBzl)-OH]-OH
N-α-Fmoc-O-benzyl-D-phosphothreonine

1 g

60557-1

5 g

60557-5

Fmoc-Tyr[PO(OBzl)OH]-OH
N-α-Fmoc-O-benzyl-L-phosphotyrosine, CAS# 191348-16-0

1 g

27259

5 g

27260

Fmoc-D-Tyr[PO(OBzl)OH]-OH
N-α-Fmoc-O-benzyl-D-phosphotyrosine

1 g

61428-1

5 g

61428-5

 

Related Products

Product

Size

Catalog nr

Fmoc-Arg(Me)2-OH (symmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (symmetrical)

250 mg

26217-F025

1 g

26217-F1

Fmoc-Arg(Me)2-OH (asymmetrical)
Fmoc-Nω,ω-dimethyl-L-arginine (asymmetrical) CAS# 268564-10-9

250 mg

26218-F025

1 g

26218-F1

Fmoc-Lys(Biotin)-Amide resin, im
N-α-Fmoc-N-ε-(d-Biotin)-L-lysine-Amide resin, im

0.5 g

23848

1 g

23849

Fmoc-Lys(Biotin)-Wang resin, im
N-α-Fmoc-N-ε-(d-Biotin)-L-lysine-Wang resin

0.5 g

21767

1 g

21769

Fmoc-D-Lys(Biotin)-Wang resin, im
N-α-Fmoc-N-ε-(d-Biotin)-D-lysine-Wang resin

0.5 g

61829-05

1 g

61829-1

Fmoc-Lys(Biotin-LC)-OH
N-α-Fmoc-N-ε-(d-Biotin-6-amidocaproate)-L-lysine

0.5 g

22505

1 g

25096

Fmoc-Lys(Biotin-LC)-Amide resin, im
N-α-Fmoc-N-ε-(d-Biotin-6-amidocaproate)-L-lysine-Amide resin, im

0.5 g

29431

1 g

29432

Fmoc-Lys(Biotin-LC)-Wang resin, im
N-α-Fmoc-N-ε-(d-Biotin-6-amidocaproate)-L-lysine-Wang resin

0.5 g

21751

1 g

21741

References:

1 Lachner, M. et al. J. Cell Sci. 116, 2117 (2003).
2 Talasz, H. et al. J. Biol. Chem. 280, 38814 (2005).
3 Schotta, G. et al. Genes Dev. 18, 1251 (2004).
4 Paik, Wk. and S. Kim, Science 174, 114 (1971).
5 Strahl, BD and CD. Allis, Nature 403, 44 (2000).