tebu-bio is a European company specialised in providing innovative reagents and laboratory services in Life Sciences
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Embryonic Hypothalamic Cell Lines

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This product line is based on a proprietary platform technology which has enabled the creation of a series of immortalized hypothalamic neurons; immortalized from mouse embryonic day 15, 17, 18 and rat embryonic day 18 hypothalamic primary cultures by retroviral transfer of SV40 T-Ag. These cell lines have been found to express an ever expanding array of neuropeptides, enzymatic markers and biologically active receptors.

Applications

As such, these cell lines enable accurate in vitro assays for use in the discovery, development and validation of new therapeutics targeted to central-nervous system diseases and disorders, including obesity, stress, and metabolic disorders, amongst others.

Some of our more popular markers include:

Peptides      
Galanin MCH CRF AgRP
Proglucagon NPY GHRH Ghrelin
Urocortin NT Arginine vasopressin Oxytocin
Orexin      
Receptors      
Estrogen Receptor alpha Estrogen Receptor beta AR NTR-1
Leptin Glp1-R Glp2-R MC4R
Insulin R MCH R1 GHS-R/Ghrelin-R PR
Adiponectin R1 & R2 NPY 1,2,4,5    
Enzymes      
Aromatase Tryptophan hydroxylase GAD 67 Tyrosine hydroxylase
Glucokinase Choline acetyltransferase    

Please download the characterisation tables, for Mouse or Rat cell line, in the "Related download" section.
 


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