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Human Bactosomes

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Bacterial membranes containing the human cytochrome P450s coexpressed with human NADPH-cytochrome P450 reductase.

Bactosomes advantages

Bactosomes can be used in conjunction with the Simcyp simulator.

Phase I enzymes available

CYP1A1            CYP1A2        CYP1B1            CYP2A6            CYP2A13      CYP2B6
CYP2C8           CYP2C9        CYP2C18         CYP2C19         CYP2D6        CYP2E1
CYP2J2            CYP3A4         CYP3A5            CYP3A7            CYP4A11      CYP4F2

Phase II enzymes available

Sulfotransferases                                        Glutathione S-transferases        Aldehyde oxidase       
UDP-glucuronosyltransferases                Carboxylesterase                         Aldehyde dehydrogenase

High or low reductase?

Bactosomes are available in High Reductase & Low reductase formats.
 

  High Reductase Low Reductase
Characteristics    
  Higher activity Lower activity
  Shorter time linearity Longer time linearity
  May not reflect in vivo  Better reflects in vivo
Applications    
  Reaction phenotyping Some reaction phenotyping
  Metabolite profiling High throughput inhibition screening
  ID minor metabolites  
  Some inhibition screening  

 

 

Note: ‘R’ = high reductase, ‘LR’ = low reductase, except for CYP2C9 (‘HR’ = high reductase, ‘R’= low reductase’)

 


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