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COVID-19 Recombinant Proteins

One of the challenges with SARS-CoV-2 immunoassay development is having access to antigens that most closely resemble the native virus proteins (e.g. which contain post-translational modifications common to the virus).

To enable you to choose the right protein for your project, we have summarised our offer below, highlighting the expression systems in which they were produced (as well as their tags and access to the full datasheets).

Nucleocapsid Protein (N-Protein)

The nucleocapsid protein (N-protein) is a structural protein that binds to the coronavirus RNA genome, thus creating a shell (or capsid) around the enclosed nucleic acid.
The N-protein also:

  1. Interacts with the viral membrane protein during viral assembly
  2. Assists in RNA synthesis and folding
  3. Plays a role in virus budding
  4. Affects host cell responses, including cell cycle and translation.
Catalog nr. Product Name Expression System Tag
100700* COVID-19 Nucleocapsid (SARS-CoV-2)   with a C-terminal His-tag CHO His tag
230-01104-* Recombinant SARS-CoV-2 Nucleocapsid Protein   N terminal His tag E. coli His tag
230-30164-* Recombinant SARS-CoV-2 Nucleocapsid Protein  with C terminal His-tag HEK293 His tag
9554 SARS-COV-2 Nucleocapsid, rec.(With DYKDDDDK Tag) HEK293 DYKDDDDK tag
9560 SARS-CoV-2 Nucleocapsid (His-Tag) Sf9 His tag

Spike Protein (S-Protein)

The spike protein (S-protein) performs two primary tasks that aid in host infection:

  1. Mediates the attachment between the virus and host cell surface receptors
  2. Facilitates viral entry into the host cell by assisting in the fusion of the viral and host cell membranes.
Spike S1
Catalog nr. Product Name Expression System Tag
100687-*    2019-nCoV Spike RBD, His-tag CHO His tag
100688*    019-nCoV Spike S1, Fc-tag CHO Fc tag
230-01101-* Recombinant SARS-CoV-2 Spike Protein, S1 Subunit    N terminal His tag E. coli His tag
230-30161-* Recombinant SARS-CoV-2 S1 Subunit Protein (full length)   His tag HEK293 His tag
9553 SARS-CoV-2 Spike protein, S1 Subunit (His-Tag), rec HEK293 His tag
100678* Spike S1, Fc Fusion, Avi-tag (SARS-CoV-2) HEK293 Avi tag, Fc fusion
100679* Spike S1, Fc fusion, Avi-tag, Biotin-Labeled (SARS-CoV-2) HEK293 Avi tag, Fc fusion, biotin labeled
9556 SARS-CoV-2 Spike Protein, S1 subunit (His-Tag), rec. Insect cells His tag
9557 SARS-CoV-2 Spike S1 N-terminal domain (NTD) (His-Tag)  Insect cells His tag

 

Spike S1 RBD
Catalog nr. Product Name Expression System Tag
100699* Spike S1 RBD, Fc fusion (SARS-CoV-2) CHO Fc tag
230-01102-* Recombinant SARS-CoV-2 Spike Protein, S1 Subunit, Host Cell Receptor Binding Domain (RBD E. coli His tag
230-30162-*    Recombinant SARS-CoV-2, S1 Subunit Protein (RBD)  His tag HEK293 His tag
230-30166-* Recombinant SARS-CoV-2 S1 Subunit Protein (RBD) with C-terminal Mouse IgG Fc Tag HEK293 Fc tag
9552 SARS-CoV-2 Spike S1 RBD Protein (His-Tag), rec.  HEK293 His tag
9558 SARS-CoV-2 Spike S1 Receptor binding domain (RBD) (His-Tag)  Insect cells His tag

 

Spike S2 subunit
Catalog nr. Product Name Expression System Tag
230-30163-10 Recombinant SARS-CoV-2 S2 Subunit Protein (full length)   with C terminal His-tag HEK293 His tag
230-01103-* Recombinant SARS-CoV-2 Spike Protein, S2 Subunit   N terminal His tag E. coli His tag
9559 SARS-CoV-2 Spike protein, S2 subunit (His-Tag), rec. Sf9 His tag

ACE2

ACE2 is an endogenous membrane protein that enables COVID-19 infection. During infection, the extracellular peptidase domain of ACE2 binds to the receptor binding domain of spike protein, which is a surface protein on SARS-CoV-2.

Catalog nr. Product Name Expression System Tag
230-30165* Recombinant Human Angiotensin-converting Enzyme 2 (ACE2) HEK293 His tag
11003* ACE2, His-Tag HEK293 His tag
100665* ACE2, His-Avi-Tag, Biotin-labeled HiP™ HEK293 His-Avi-Tag,
Biotin-labeled HiP™
100702* ACE2, His-tag (Monkey) HEK293 His tag
100701* ACE2, Fc Fusion (Monkey) HEK293 Fc tag