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My accountHepatocytes - a viable & cost-effective alternative to in vivo testing
Hepatocytes are commonly used in drug discovery and preclinical drug development to perform experiments requiring intact cellular systems. Intact hepatocytes contain the major hepatic drug-metabolizing enzymes required to study the four categories of xenobiotic biotransformation: hydrolysis, reduction, oxidation and conjugation. Because of these enzymes, hepatocytes provide a viable and cost-effective alternative to in vivo testing.
tebu-bio offers the widest variety of hepatocyte products, with pool sizes ranging from individual donors to 100-donor pool, human & animal, fresh & cryopreserved, plated & suspension.
Human Cryopreserved Hepatocytes
| Name | Number of donors | Characteristics | Applications |
|---|---|---|---|
| HepatoSure™ | 100 (50 M + 50 F) |
* Suspension * Largest pool on the market |
Metabolic stability
Metabolite profiling
Enzyme inhibition
Uptake assays
Enzyme phenotyping
|
| CryostaX™ | 2 to 20 |
* Suspension |
Metabolic stability
Metabolite profiling
Enzyme inhibition
Uptake assays
Enzyme phenotyping
|
| CryostaX+ | 5 or 10 |
* Attaching * Single-freeze pooled |
Metabolism Transporters |
| Cryoplateable Hepatocytes | 1 (M or F) |
* Attaching * Fold Induction for CYP1A2, 2B6 and 3A4: mRNA levels & enzymatic activities * CITCO & Phenobarbital for 2B6 |
Long-term metabolic stability Induction Toxicity Transporter studies |
| Qualyst Transporter Certified™ Plateable Human Hepatocytes | 1 (M or F) |
* Attaching * Certified to culture for 5 days and maintain both uptake and efflux transporters as well as proper bile canaliculi formation
|
Long-term metabolic stability Induction Toxicity Transporter studies |
| Geneknown™ hepatocytes | 3 |
* Evaluated for the presence of significant alleles and SNPs for 30 genes
|
Study the effects of individual genetic variants |
| Single-Donor Human Hepatocytes | 1 (M or F) | * Suspension | phase I and II in vitro drug metabolism studies |
Extend your metabolism and toxicity studies with Kupffer Cells, Liver MyoFibroblasts, Stellate Cells, Hepatic progenitor cells, Renal tubular epithelial cells, etc
Animal Hepatocytes Cryoplateable
Sprague Dawley, Wistar and Wistar Han rat, CD-1 mouse, and Cynomolgus monkey cryoplateable hepatocytes. If your study requires cryoplateable hepatocytes from a different species, contact one of our product specialists to find out how ’s our custom products can meet your needs.
| Species | Species |
|---|---|
| Cynomolgus Monkey | Sprague-Dawley Rat |
| Mouse CD-1 | Wistar Rat |
| Wistar-Han Rat |
Animal Hepatocytes Suspension
Animal hepatocytes provide a cost-effective alternative to human hepatocytes and can be used to guide species selection for in vivo ADME services.
We feature cryopreserved hepatocytes from six toxicologically relevant species including monkey, minipig, dog, rabbit, rat and mouse. Hepatocytes from male and female pools are available for most species. We also offer custom products to meet the specific needs of any study.
| Species | Species |
|---|---|
