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PKmito™: Efficient probes for gentle mitochondria imaging!

Mitochondria is in the spotlight! 

For the first time, access these wonderful probes, specific to mitochondria, and move your research in imagery forward. PKmito™ probes have been developed and published by the lab of Zhixing Chen from Peking University1,2.

  • Very low phototoxicity
  • Good STED performance
  • No genetic manipulation, transfection or overexpression of fluorescent proteins needed

 

And many more advantages we invite you to discover...

 

                                                                                                                                                         Live HeLa cells labeled with PKmitoTM ORANGE and picogreen (mtDNA). 

Interested in trying them? Now is the time to discover these products, at a very special discounted price.                 

                                                                                                                                                           

Order now and get 50% off PKmitoTM probes 

 


Offer valid up to March 31st, 2023 - mention promo code "PKmito50" on your order to benefit from this discount.
For more information or to order, please contact your local Tebubio office.
Non-cumulative with any other discounts, special offers or price agreements.

  

PKmitoTM benefits

PKmito™ probes feature a unique technology: they consist of cyanine derivatives bearing intramolecular cyclooctatetraene (COT) substituents. The presence of intramolecular COT substituents very efficiently reduces the production of singlet oxygen. Singlet oxygen is a very reactive species produced by fluorophores and it is responsible of rapid cellular damage leading to cell death.

PKmito™ probes therefore allow very gentle imaging of mitochondria in live cells and tissues and preserve them from singlet oxygen damage and phototoxicity.

 

 

  • Very low phototoxicity: Allows you to record timelapse STED movies (ca 20 frames) without damaging or changing the mitochondria morphology.

  • Super-resolution Microscopes Compatibility: Can be used for widefield, confocal or STED imaging in living cells and tissue.

  • Very Specific: PKmito ORANGE is the ideal STED probe for mitochondria, staining the inner membrane and therefore revealing mitochondrial cristae (sub diffraction structures impossible to see with conventional microscopes). 

  • Multicolor imaging: Compatible with SIR & SPY probes.

 

 

                 

 

                  

         Super-resolution
   Microscope Compatibility

Very Specific     Non Toxic

                                                    

 

Order your PKmitoTM probes now

 

 

 

Multicolor imaging for multiple analysis

Do you want to perform advanced analysis? PKmito probes enables multicolor imaging with other Spirochrome's probes: SiR & SPY probes. Thanks to PKmitoTMs amazing capabilities, you'll get an outstanding tool to study mitochondria!  

                                                                                

 


1. Liu Tianyan et al. “Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain” PNAS (2022):119 (52).
2. Yang, Zhongtian, et al. “Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging.” Chemical science 11.32 (2020): 8506-8516.