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Celtarys - New fluorescent ligands to characterise your GPCRs

As highly studied drug targets, GPCRs are involved in many different pathologies.

However, in the process of exploring the mechanism of drugs and GPCRs, detection and visualisation remain challenging, partly due to the lack of validated reagents.

Celtarys, with more than 20 years of experience in GPCRs, has developed a series of new GPCR fluorescent ligands, which allow to rapidly implement quantitative assays in drug discovery programs (High Throughput Screening) and chemical biology programs (Target Engagement studies), being compatible with emerging fluorescent technologies.

Key Values

  • High specificity: Potent (Ki < 100 nM) and subtype selective ( >100-fold)
  • Fluorophore Stability: guarantee their affinity and meet the market demand from competitive biding assays to microscopy.
  • Pharmacophores: aligned with international standards and representative of the target
  • Spacers : allow optimal target recognition and placing of the fluorophore in the outer region of the membrane

Fig1. Simplified structure of a fluorescent ligand

Fluorescent Ligands are validated for numerous applications 

Celtarys fluorescent ligands have been extensively characterized, and come with with detailed protocols in order to help you to easily perform a variety of fluoresce-based assays. Also, they are validated for different applications such as live-imaging microscopy, HTRF (Homogeneous Time Resolved Fluorescence), HCS (high content screening), fluorescence polarisation, flow cytometry...

Access Celtarys ligands

The validated ligands are available for different subtypes

Adenosine receptors: A1, A2A, A2B, A3                                         Serotonin receptors: 5HT2A, 5HT2B, 5HT2C
 
Cannabinoid receptors: CB1,CB2                                                   GLP1 receptors
 
Dopamine receptors: D2, D3, D4                                                    Muscarinic receptors
 


Browse the Celtarys portfolio and select your suitable ligands

 

Read our blog posts to learn more about the advantages of fluorescent ligands over antibodies & radioligand methods, and see more detailed cases:

Are fluorescent ligands the best tool to characterise GPCRs? 
Fluorescent ligands: a new method to label GPCRs