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New Recombinant UGTs!

CYPEX, specialized manufacturer of active recombinant drug metabolising enzymes, have just released new UGTs expressed in Sf9 cells.

Available isoforms and their typical calculated Vmax

Isoform Substrate Typical Vmax
(pmol/min/mg)
Cat #
UGT1A1 17β-estradiol 700 CYP201
UGT1A3 17β-estradiol
4-methylumbelliferone
120
700
CYP202
UGT1A4 Trifluoperazine
(N-glucuronide formation)
500 CYP207
UGT1A7  4-methylumbelliferone 30000 CYP206
UGT1A8 4-methylumbelliferone 8000 CYP203
UGT1A9 Propofol
4-methylumbelliferone
2500 (-alamethicin)
7000
CYP205
UGT1A10 17β-estradiol
4-methylumbelliferone
12000
6000
CYP204
Control Sf9 Microsomes N/A N/A CYP208