April 2016

Toxicity Assessment of Co-Culture Human Systems

Many chemotherapeutic drugs require bioactivation before they reach full potency. 

This bioactivation is accomplished through many different mechanisms but is frequently accomplished in the liver before the drug enters circulation. The inadequacy of animal models to predict human biology in the drug development process is becoming increasingly clear due to species differences in uptake and metabolism at both the cellular and organ levels.

The feasibility of creating a multi-organ system capable of testing the ability of a human liver cell line to activate a panel of chemotherapeutic drugs has recently been demonstrated. 

  Download the poster presented at SOT2016 about this technology

Solute Carrier Transporter studies made easy

Solute carrier (SLC) transporters are located in the small intestine, liver, kidney, blood-brain barrier, and so on. They play a role in the up-take of various drugs, as well as endogenous nutrients into cells and thus may influence the ADME properties of, or indeed adverse reactions to, a compound of interest. Thus, investigation of SLC transporters is expected to be helpful during drug development.

Now, you can easily access SLC research tools, licenced with a patent which fully covers your use of the cell lines including your publications. The  TRANSiPort product line is available across Europe through tebu-bio.

 Be sure of your results without infringing any patents

Genetic polymorphisms in CYP450 family impact on drug-drug interaction liability. XenoTech's Geneknown™ hepatocytes are characterized for pharmacologically relevant polymorphisms affecting the ADME-Tox properties of xenobiotics.

is the number of new media...

...developed to improve attachment efficiency, cell culture, dosing and thawing of cryopreserved hepatocytes.

  Browse the list of Geneknown™ Hepatocytes

 Discover the procedures in videos

Quick solution for supporting long-term metabolism

XenoTech’s RapidStart™ NADPH Regenerating System offers the easiest activation process on the market – just add water and you’re done! RapidStart™ is not only easily activated, but is the most flexible NADPH regenerating system you’ll find, allowing users to easily manipulate the system concentration by simply varying the amount of water added.

 Add – Agitate – Activate!

Save your seat - "Evaluation of Ketoconazole and its alternative clinical CYP3A4/5 inhibitors as inhibitors of drug transporters"

Ketoconazole is known to be a strong CYP3A4/5 inhibitor, and until recently, was utilized in this role in clinical drug-drug interaction (DDI) studies. Unfortunately, Ketoconazole has also demonstrated the ability to cause sporadic liver injury or adrenal insufficiency. The purpose of the study that will be discussed, was to determine the inhibitory effects of Ketoconazole, Ritonavir, Clarithromycin and Itraconazole on 13 clinically relevant drug transporters.

  Register now and join us on April 13th.

Choose your topics! Subscribe to tebu-bio's newsletters on your favourite research themes