Drug Discovery
Epigenetics Focus

November 2015

Epigenetic mechanisms act on the regulation of DNA transcription and thus on gene expression regulation, without affecting the DNA sequence itself. Epigenetics is one of the fastest-growing fields in research as well as in Drug Discovery.

Take a look at a selection of posts by our specialists published on our blog Being Bioreactive, covering this domain.

Histone Deacetylases (HDACs) and Alzheimer

Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. In this post, our specialist Ali focuses on the role of HDACs in Alzheimer’s disease, which accounts for 60 to 70% of dementia cases. He reviews a selection of tools to facilitate your HDAC related Alzheimer research and screening activities. [ Read more ]

Histone Deacetylases (HDACs) and Cancer

HDACs are overexpressed and show very high activities in a number of tumor cells, can even be used as a cancer biomarker, and play a crucial role in oncogene expression. Here, Ali presents the latest products available for your cancer research. [ Read more... ]

Keen to work with the best quality nucleosomes?

Nucleosomes are basis units of DNA packaging in eukaryotic cells. They are directly involved in the regulation of several nuclear processes like transcription, replication or DNA repair. In this post, Ali gives some keys for choosing the best ones for your in vitro assays related to inhibitor screening, epigenetics studies and chromatin reconstitution. [ Read more... ]

How to assess Histone antibody specificity and quality

The specificity of antibodies to histone modifications is crucial for obtaining meaningful experimental data. Rothbart and co have used a unique quantitative histone peptide array to investigate the specificity of more than 100 commercially available histone modification antibodies, raised against 43 unique modifications at 33 distinct residues... [ Read more... ]

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