Cell Biology and Signalling 

October 2015

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Live cell imaging of DNA with SiR-DNA for STED & SIM

 In their most recent publication “SiR-Hoechst, a far-red DNA stain for live-cell nanoscopy” in Nature Communications, Lukinavičius et al. define ideal characteristics of a nuclear stain for live cell imaging approaches. 

None of the nuclear stains on the market meets all these crucial requirements leading thus to the need for a new tool for live cell staining experiments of the nucleus.

Discover Sir-DNA, your new tool for live cell imaging


Most comprehensive range of Live Cell Imaging tools

Visualizing fixed cells and tissues only gives snap shots of cellular processes. To get a better insight into dynamic processes in cells and interactions between cellular components, be it proteins or even organelles, more and more powerful microscopic tools have been developed over the past decade to image living cells.

Get all your Live Cell Imaging tools at tebu-bio.com

Cell-clock: measure the 4 major phases of cell cycle

The Cell Cycle is the whole series of steps which constitute and define the life of the cell. This cycle consists of several phases of  growth, when the cell grows and duplicates its genetic material (interphase), and one phase where the cell divides (mitosis or meiosis) to give rise to 2 identical daughter cells (for mitosis). Daughter cells reproduce this cycle and so on. 

Cell cycle checkpoints control the process to ensure correct division of the cell.

How do you measure the major phases of the cell cycle in cells?


Tubulin and microtubule vizualization in cells

Tubulin represents one of the major cytoskeleton structures. It plays an important role in cell structure, intracellular transport, and mitosis. In eukaryotic cells, microtubules are assembled from dimers of α-tubulin and β-tubulin which form a filamentous cylinder. This is the first publication of a series, that will be dedicated to tubulin visualization, binding and polymerization as well as measurement of the tubulin vs. microtubule ratio... [ Read more ]


The Ras superfamily of small G proteins consists of more than 150 members which can be divided into five main families – Ras, Rho, Ran, Rab and Arf. They control divse cellular behavior (cell growth, differentiation and motility). Consequently, small GTPases are involved in a several disease such as cancer and metabolic disorders.

In this post, we invite you to discover some state-of-the art methods to measure the activation of the most prominent small G proteins.

Measure the activation of small G proteins

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