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In vitro exploration of hepatobiliary drug disposition

An integrated in vitro model maintains physiologic cellular components and processes at in vivo-relevant amounts. In the sandwich-cultured hepatocyte model, relevant drug transporter proteins (uptake and efflux), as well as drug metabolizing enzymes (Phase I and II), are expressed, maintained, and functioning together in the same system.

What is an integrated hepatic model and why is it important?

Maximise availability & reduce variability in hepatocyte studies

Cryopreserved hepatocytes are nowadays highly characterised, and their functionality is very close to that of freshly isolated ones.
The main problem now is obtaining a pool which is representative of a defined population… along with guaranteed sourcing…

Discover how HepatoSure can help you


Meet us at these events!
20th International Symposium on Microsomes & Drug Oxidations

We'll be in Stuttgart from May 18th to 22nd at the MDO - an international symposium series for the science of drug metabolism, drug metabolizing enzymes & related areas.

6 tips for thawing hepatocytes

Cryopreserved hepatocytes are ready when you are. A simply quick-thaw protocol is performed to remove cryoprotectant and obtain viable cells…
However, the functionality and the viability of your cells could be impaired by incorrect thawing procedures...

Get it right every time! the number of donors in our Human Liver microsome pool

Minimized lot-to-lot variability by use of the most representative pool from global population...
availability through large production capability for long term supply...

Explore the products


Meet up with our specialist Gladys Verelst in Egmond aan Zee from June 10th to 13th, at the 18th international meeting of the European Society of Toxicology In Vitro.

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