Discovery Tools

June 2015

News Highlight

Direct localization of MMP activity in 3D tumor invasion model

Recently, the non-FRET EnSens technology was launched for in vitro assessment of specific protease activities. Up to date, the EnSens substates were validated for the detection of protease activity in microplate assays. Now, we're pleased to report that Enzium has extended the applicability of their Ensens method to 3 D live-cell imaging. On the top of this, the experimental procedure is easy and non-toxic for cell cultures and co-cultures.


New Fluorescent Labeling and Detection Products

For decades researchers have been using the famous Alexa Fluor® dyes developed by Molecular Probes for everything from flow cytometry to oligonucleotide labeling. The original Molecular Probes patents have likely limited the number of companies offering less expensive alternatives to the Alexa Fluor® dyes. Innovative dyes as DyLight® and IRDyes® have been developed and are used for specific applications, but direct alternatives for the standard Alexa Fluor® exitation and emission spectra dyes have been difficult/impossible to find…..until now.


Column-free, Caustic Solvent-free DNA or RNA Purification

Epicentre® (an Illumina Company) has developed a series of MasterPure™ DNA and RNA purification kits for nearly any sample type.
These kits offer a simple protocol for the purification of genomic DNA, cellular RNA, or total nucleic acid (TNA).

A limited number of free samples of MasterPure™ Complete DNA and RNA Purification Kit (325 Euros value) are available for European Scientists.
Contact Mark to discuss your project.

Learn more about MasterPure™ purification kits

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Current News

Identification of a MicroRNA signature for Fibromyalgia diagnosis

"A recent paper by Cerdá-Olmedo, G. et al. unravels the miRNA signature in fibromyalgia (FM). Diagnosis of FM, a chronic musculoskeletal pain syndrome characterised by generalized body pain, hyperalgesia and other functional and emotional comorbidities, is a challenging process hindered by symptom heterogeneity and clinical overlap with other disorders. No objective diagnostic method exists at present...."

Read more

New drug for Sickle Cell Disease targets Leukocytes

Leukocytes adhere to blood vessels as a mechanism to enter tissue where there is inflammation. Inadvertently, they pile up sickle cell red blood cells. Mutations in the hemoglobin gene can render a person to a lifetime of sickle cell disease (SCD). There is a new drug, GMI-1070, that is being explored for SCD.

Read more

G-LISA or bead-based pull-down assays?

Participate in our Webinar on June 24th, and  see how easy it is to measure activation of Small GTPases in cell and tissue lysates.

Learn more & sign up today!

Technical Corner

Measuring total ubiquitinated proteins in cell lysates – made easy!

"To date, detecting changes in the ubiquitylation of specific substrate proteins in response to external stimuli, e.g. stress, cytokine exposure, drug candidate treatment, etc., has been a long, labor-intensive process involving immunoprecipitation followed by gel electrophoresis and Western blot analysis. This method is low through-put, resource intensive, and only semi-quantitative at best....". Read more...

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