Acting and reacting in Life Sciences and Biotechnologies

Acting and reacting in life sciences and biotechnologies

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JUNE 23, 2017

Acting and reacting in Life Sciences and Biotechnologies

What is "being bio-reactive"? We define it as opening new doors, exploring new areas, staying informed about breaking news & developments in Life Sciences and the fast evolving world of biology.

Here's a selection of recent information & events from our blog...

Stable Cas9-expressing cell lines

21/06/2017 BY DIMITRI SZYMCZAK

Shen et al (Nature Methods, 2017) explore and identify synthetic interactions among 73 cancer-associated genes. To perform their loss of function screen they combined CAS9-expressing cell lines with a sgRNA library of high titer lentiviral particles. Most of these gene interactions were subsequently validated by drug treatment.... [ Read more ]

New range of Pig P450s Bactosomes

19/06/2017 BY ISABELLE NOBIRON

If you are looking for enzymatic in vitro tools for drug metabolism, reaction phenotyping, metabolite generation, using pig as model, you may find these newly released Pig Bactosomes from Cypex of interest. Bactosomes are recombinant enzymes expressed in E. coli with a patented expression system that enables expression of drug metabolising enzymes without the need for large modifications to be made to the proteins.... [ Read more ]

New in Live Cell Imaging: CopperGREEN and GlycoGREEN probes

14/06/2017 BY FREDERIC SAMAZAN

One of our aims is to offer you, the researcher, a large and varied selection of biologically relevant, innovative Live Cell Imaging tools. In 2016, we started a collaboration with Goryo Chemical, when our specialists selected their unique fluorescent dyes for cellular analysis, assays and live cell imaging. Today, I’d like to take you through two new fluorescent probes... [ Read more ]

Metabolite production made fast and easy - BMO Kits

13/06/2017 BY ISABELLE NOBIRON

Metabolite characterization can be a lengthy process making your in vitro drug testing time consuming and expensive. Whether you are working on phase I or phase II metabolic enzymatic reactions, take a look at these BMO kits which can help you speed up this characterisation process. The BMO kit mimics the suite of cytochrome P450 enzymes (CYP) present in human hepatocytes, offering you a unique synthetic chemical liver.... [ Read more ]

Single domain antibodies: Novel Llama immunoreagents

09/06/2017 BY ISABELLE NOBIRON

A single-domain antibody (sdAb, also called Nanobody) is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDA, single-domain antibodies are much smaller than common antibodies (150–160 kDa). They have been shown to be just as specific as a regular antibody and in some cases more robust.... [ Read more ]

OTHER ARTICLES OF INTEREST...

New TIGIT:CD155 cell-based assay to restore immune response

 Maximize messenger RNA therapeutic activity with innate immune focused approaches

Sekisui XenoTech Awarded Cryopreservation Patent for Cryostax single freeze hepatocytes