Stem Cell & iPSC research, 3D Cell culture tools, 1-shot broad protein profiling, ...
Acting and reacting in Life Sciences and Biotechnologies

Acting and reacting in life sciences and biotechnologies

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APRIL 21, 2017

Acting and reacting in Life Sciences and Biotechnologies

What is "being bio-reactive"? We define it as opening new doors, exploring new areas, staying informed about breaking news & developments in Life Sciences and the fast evolving world of biology.

Here's a selection of recent information & events from our blog...

Stem cell and iPSC research: quality and innovative products to boost your project

21/04/2017 BY ISABELLE NOBIRON PhD

Since the discovery of reprogramming factors in 2006 and the boom of CRISPR engineering strategies, iPSC cell lines have emerged as new cellular models. The development of 3D culture technologies has also contributed to the generation of iPSC derived cells, with unique applications from patient-specific drug responses testing, to regenerative medicine. I would like to introduce in this post a selection of reagents in this domain, a combination of both routine and innovative quality reagents... [ Read more ]

Stem cell and iPSC research: quality and innovative products to boost your project

Broad protein profiling in one shot: up to 1000 targets with L-Series

19/04/2017 BY ISABELLE NOBIRON PhD

In a previous post dedicated to Quantitative arrays (Quantibody), I introduced our L-Series aimed at a broad one shot profiling of up to 1000 markers at once. This relative quantitation technology allows you to perform a first screen of your samples of interest versus a control, before you go on to targeted profiling using either pathway specific arrays, or a custom array including the targets of interest identified with the initial L-series screen.... [ Read more ]

Broad protein profiling in one shot: up to 1000 targets with L-Series

3 novel PD-L1 post-translational modifications identified

18/04/2017 BY PHILIPPE FIXE

In a recent paper, Horita H. et al. identified a set of novel Post-Translational Modifications (PTMs) of the protein Programmed Cell Death Ligand (PD-L1). For this, a novel series of PTM enrichment assays  enabling the highly specific profiling of 4 key PTM profiles (Tyrosine phosphorylation (pY), Acetylation (Ac), Unbiquitination (Ub) and SUMOylation 2/3), have been used on EGF-stimulated A431 cell line.. [ Read more ]

3 novel PD-L1 post-translational modifications identified

New innovative cell culture devices for more predictive 3D models

05/04/2017 BY FREDERIC SAMAZAN

One of the biggest challenges as a researcher in life sciences, is to obtain proof of concept the more predictive as possible. To help you to reach your objectives, many innovative tools are being developed and new techniques are emerging. In this post, I'd like to essentially focus on two innovative cell culture devices which mimic in-vivo conditions in in-vitro systems, in fields such as 3D cell culture, Microfluidics and Oriented cell culture.... [ Read more ]

New innovative cell culture devices for more predictive 3D models

Stauprimide inhibits c-myc transcription in cancer cells

04/04/2017 BY PHILIPPE FIXE

Stauprimide is known to prime Embryonic Stem Cells (ESC) by targeting the c-Myc-activating transcription factor NME2. Its mechanism of action is linked to the inhibition of the nuclear localization of NME2 leading to the downregulation of the transcription of the c-myc oncogene. In a recent study, Bouvard C. et al. evidenced that Stauprimide's mechanism of action could also be used to pharmacologically targetc-myc transcription in cancers. ... [ Read more ]

Stauprimide inhibits c-myc transcription in cancer cells

NEWS IN BRIEF...

AACR2017 Poster download - Modulation of CAF expressed podoplanin activity in TME

AACR2017 Poster download - Modulation of CAF expressed podoplanin activity in TME