Fully characterized in vitro test reagents

From Hepatocytes and optimized media to human and animal subcellular fractions, from lysosomes and tritosomes to Human bactosomes and standardised EasyCyp or recombinant CYP, transporter validated cell lines to metabolite screening kits, down to hiPSC derived hepatocytes… the range of products we offer covers most ADME-Tox applications: metabolism studies, in vitro toxicity, enzyme induction and inhibition, reaction phenotyping, genetic polymorphism, transporter studies…

Human hepatocytes Large Donor Pools for representative populations

• Hepatosure™ provide an extensively characterized pool of 100 donors for a representative of average population

Patented single-freeze hepatocytes for customized pools of sub-populations

• CryostaX™ is a unique, patented, pooled human hepatocyte product where individual donors are represented as pellets. These pellets allow for on-demand custom pooling and large lot sizes, resulting in long-term availability of custom hepatocyte lots

Hepatocytes for pharmacologically relevant genetically-defined sub-populations

• Geneknown™ are evaluated for the presence of significant alleles and SNPs for 30 genes:
  • CYP1A1, 1A2, 2A6, 2B6, 2D6, 2C8, 2C9, 2C19, 2E1, 3A4, 3A5
  • MDR1, MRP2, BCRP, PEPT2, OCT1, OCT2, OAT1, OATP1B1, OATP1B3, OATP2B1
  • DPYD, GSTP1, NAT1, NAT2, TPMT, UGT1A1, UGT2B15, UGT2B7, VKORC1

Fully characterized attachable lots

• Single donor cryopreserved plateable hepatocytes, characterized for CYP, general UGT and SULT activities, and for induction applications (CYP1A2, CYP2B6 and CYP3A4).

Certified, FDA approved transporters tools for DDI studies

These ready-to-use cell lines over-expressing FDA recommended transporters are a very cost effective format for quick and easy DDI studies. We can perform the plating step for you in our own laboratories if you’d rather outsource this part of your project.

Robust customization capacities

If your ADME research demands quality data from a unique test system, our partner Sekisui XenoTech is equipped to help meet those demands with an extensive experience preparing hepatocytes, subcellular fractions and other cells from a wide variety of species and tissue.

Access our ADME-Tox toolbox - easily access all the reagents you need

tebu-bio laboratories - expertise and proximity

Outsource your assay to us - your assigned project manager will work with you to build your experimental design in full confidentiality, and keep regular contact with you at all steps of your project.

Examples of services performed in house:

• Nuclear receptor activation screening
• Caco2 plating, amplification and screening service
• Physiologically relevant 3D cell culture spheroid platform
• Compound Screening platform
• Protein multiplex quantification

Contract services

In collaboration with our partner Xenotech, we offer most standard in vitro ADME tests as service: enzyme inhibition and induction studies, drug transporters and biologic DDIs, metabolite ID and in vitro toxicity, species comparison, protein binding tests. Just contact us if you would like to discuss a specific project with us.