Insulin and Glucagon are involved in glucose homeostasis in addition to other factors secreted by the adipose tissue (adipokines). Insulin and Glucagon are produced by the endocrine pancreas. While Glucagon is released by alpha-cells of the islets of Langerhans to raise glycemia when blood glucose levels fall too low, Insulin has the opposite effect. Insulin is produced by beta-cells of the islets of Langerhans. It allows glucose to be taken up from the bloodstream when blood glucose levels are high and to be used by insulin-dependent tissues (liver, skeletal muscles, fat tissue…).
Let’s take a look at a selection of immuno-assays and primary cells for analysing these two hormones and the recentlly launched primary Human Islet cells.