In a previous post dedicated to Quantitative arrays (Quantibody), I introduced our L-Series aimed at a broad one shot profiling of up to 1000 markers at once. This relative quantitation technology allows you to perform a first screen of your samples of interest versus a control, before you go on to targeted profiling using either pathway specific arrays, or a custom array including the targets of interest identified with the initial L-series screen. [Read more…]
On your journey to Biomarker profiling, you will reach the point where you need to quantify the proteins of interest identified along the way (eg. validation of semi-quantitative array results; biomarker discovery with an initial hunch on which pathway is involved).
At this stage, you will have narrowed down the number of targets you want to look at. However, the use of ELISAs is likely to be still too costly, too time consuming, and may require too much sample volume. [Read more…]
The JAK/STAT pathway is an important signalling process for numerous cytokines and growth factors.
Its activation is essential to many processes such as hematopoiesis, immune development, growth, adipogenesis, mammary gland development… [Read more…]
Breaking news for cancer researchers! We are pleased to have recently added innovative cancer Arrays to our product offer. You might tell me that there are a lot of new cancer arrays every year and it’s not really necessary to write a post about it… but read on and I’m sure you’ll share my enthusiasm!
Obesity is the abnormal increase in adipose tissue mass. This phenomenon increases the likelyhood of a number of diseases such as heart disease, high blood pressure, type 2 diabetes, obstructive sleep apnea, osteoarthritis, and some kinds of cancer.
Obesity is probably the leading preventable cause of death worldwide. People are considered to be obese if their body mass index (BMI) exceeds a value of 30. The mainstays of treatment of obesity remain dieting and physical exercise.
Nevertheless, adipose tissue (fat) cannot be considered a worthless batch of “lard”, but rather a fascinating vital tissue that in addition to being the body’s major energy reservoir, plays a central role as a secretory organ. Research in this field has already lead to exciting results related to both fat reduction, insulin resistance and to the development of robust tools to study diabetes / obesity.
Adipokines are factors secreted by adipose tissue which carry messages to other parts of the body. I would like to briefly introduce the role of adipokines in the regulation of body weight and glucose homeostasis. [Read more…]
Pr. Ruo-Pan Huang’s team has just published a review detailing the interactions between cancer and immune cells.
This overview describes the key cytokine signals, cell–cell signal networks in the tumor microenvironment during cancer diseases. It also demonstrates the power of antibody arrays and multiplex immunoassays as unique research tools to decipher cytokine networks during cancer and inflammation processes.
Brett Burkholder et al. “Tumor-induced perturbations of cytokines and immune cell networks” (2014) BBA – Reviews on Cancer, Vol. 1845 no. 2, 182–201. DOI http://dx.doi.org/10.1016/j.bbcan.2014.01.004