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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Cell Sourcing - Cell Culture Technologies, Headlines, Stem Cells, Supplying Discovery Tools

5 most popular posts in Stem Cells in 2015

06/01/2015 by Jean-François Têtu, PhD No Comments
Feeders Cells for Stem cell research

Following on from the 5 most popular posts in Cell Sourcing, today let’s look back at the 5 most visited blog posts in 2014 in the field of stem cells.

images#1 – Induced pluripotent neural stem cells in screening assay

Introducing Human Induced Pluripotent Stem Cells as a promising option for researchers creating in vitro models for the study of neurodegenerative diseases. We also highlight the benefits of using human iPS-derived neural cells vs. rodent primary neural cells.

 

4-Maintains Normal Karyotype after 20 Passages#2 – Cost-effective serum replacer for stem cell culture!

FBS is an inherently variable component of the cell culture system, so consistent performance demands extensive screening of manufactured lots. To circumvent this problem, companies began offering “stem cell qualified” serum… discover more in this post!

 

Comparison of standard reprogramming methodologies#3 – mRNA reprogramming system: fastest & safest!

Early reprogramming methods utilized retroviral (including lentiviral) vectors to introduce reprogramming-associated transcription factors to the target cells. While these pioneering experiments provided a fundamental proof-of-concept, these vectors required the integration of heritable viral DNA sequence into the host cell’s genome… Discover the benefits of a new mRNA reprogramming system!

 

EGF StemBeads vs soluble EGF in IF staining of E14 and E18 Cortical cells tebu-bio

#4 – Recent advances in Stem Cell culture: Encapsulated Stembeads growth factors

How can I optimise my media to cultivate Stem cells with stable and cost-effective Stem Cell Factors? Find all the answers in this post!

 

c0b67d286c-DopaCell_Spec_Picture3

#5 -Isogenic Knockout iPSC Lines for Modeling of CNS Disorders

Knockout iPSC lines that mimic loss of function of genes associated with various CNS disorders as novel tools for controlled experiments to decipher functionality of each disease‐associated gene, and thus the mechanism underlying the disease.

 

We hope you found these posts of interest, stay up to date in 2015 by following our future articles!

Cell Biology and Signalling, Supplying Discovery Tools

Validated antibodies for Ectodermal Stem Cell Lineage

04/12/2014 by Philippe Fixe, PhD No Comments

Self-renewal and differentiation capacities into multiple cell-types are 2 main characteristics of Stem Cells. Contrarily to Embryonic Stem Cells, Adult Stem Cells (ASC) are already committed to a differentiated lineage. Nevertheless, ASC still retain capacities of generating various cell types within their restricted lineage. It’s thus crucial to be able to access high quality and reliable research tools when tracking cell differentiation. Here, we’ll review the most popular reagents used to characterize the ectodermal lineage.

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ChAT+ neurons and neurogenesis by Paez-Gonzalez et al. (Duke University)

05/06/2014 by Philippe Fixe, PhD No Comments

Paez-Gonzalez et al. (Duke University) have discovered a new population of choline acetyltransferase (ChAT)+ neurons present in the rodent subventricular zone (SVZ). (1) This niche is known to be important in neurogenesis activity.

These ChAT+ neural cells have their own functional and structural characteristics. By example, optogenetic studies  showed that ChAT+ neurons are necessary and sufficient to modulate neurogenic proliferation. The authors also found local interaction between SVZ Neural Stem Cells and acetylcholine locally released and synergic effects with FGF-R activation to raise neuroblast production.

The authors thus revealed an new gateway suggesting possibilities for modulating neuroregenerative capacities in health and disease as if “Neuron Tells Stem Cells to Grow New Neurons”. (2)

Sources:

(1) Patricia Paez-Gonzalez, Brent Asrican, Erica Rodriguez, Chay T Kuo”Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis” (2014) Nature Neuroscience. DOI:10.1038/nn.3734
Duke University School of Medicine, Durham, North Carolina, USA.

(2) Neuron Tells Stem Cells to Grow New Neurons –  Researchers identify first piece of new brain-repair circuit (2014) by  By Karl Leif Bates

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