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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
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ADME-Tox, Cell Sourcing - Cell Culture Technologies, Headlines, Supplying Discovery Tools

6 tips for thawing hepatocytes

05/05/2014 by Jean-François Têtu, PhD No Comments

Cryopreserved hepatocytes contain the major hepatic drug-metabolizing enzymes required to study the four categories of xenobiotic biotransformation: hydrolysis, reduction, oxidation and conjugation. Cryopreserved hepatocytes are ready when you are. A simply quick-thaw protocol is performed to remove cryoprotectant and have viable cells… However, the functionality and the viability of these cells can be impaired by an incorrect thawing procedure…

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ADME-Tox, Cell Sourcing - Cell Culture Technologies, Supplying Discovery Tools

Activation & de-activation pathways of hepatic fibrosis

15/04/2014 by Jean-François Têtu, PhD No Comments
Liver fibrosis is the result of an imbalance between production and dissolution of extracellular matrix. It has been described that Stellate cells, liver myofibroblasts, and bone marrow derived cells converge in a complex interaction with hepatocytes and immune cells to induce response to liver injury.
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