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Research areas
    ADME-Tox
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    Cell Sourcing - Cell Culture Technologies
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    Gene Expression - Molecular Biology
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    Supplying Discovery Tools
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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Drug Discovery

Cancer immunotherapy: IDO1 inhibitors – reversible or irreversible?

17/03/2016 by Ali El Baya, PhD No Comments
IDO1 - Tryptophan Catabolic Pathways

Fig 1: IDO and TDO – Tryptophan Catabolic Pathways

Trpytophan (trp) is an important and essential amino acid that has a variety of functions within the cell. In addition to being incorporated into the polypeptide chain of proteins, various catabolic pathways can produce a number of functional Trp derivatives. Trp is the biosynthetic precursor of the co-factor NAD, a number of antibiotics, and the neurotransmitters serotonin and melatonin.

The factors regulating the fate of Trp in the cell have yet to be fully elucidated, but likely involve specific enzymes that may vary in expression levels or with the cell type (Fig 1 – Shown is a depiction of two important tryptophan catabolic pathways and the enzymes that participate in the process).

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Drug Discovery

IDO and TDO – Cell based & biochemical assays

12/10/2015 by Ali El Baya, PhD No Comments

 

Which roles do IDO and TDO play in Immunotherapy? Immune evasion is one of the identifying hallmarks of cancer and researchers are investigating the complex mechanisms that enable cancer cells to evade the host’s immune system. In the context of a tumor, Tryptophan (Trp or L-Trp) catabolizing enzymes have been shown to assist cancer cells in immune evasion.

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Drug Discovery

Immunotherapy Screening – IDO pathway

24/03/2015 by Ali El Baya, PhD No Comments

In previous blogs, I invited you to join me in exploring the relevance of the following pathways:

PD1 - PD-L1 - PD-L2

  • B7-1 : CD28, B7-1 : CTLA4
  • BLTA:HVEM, CD47:SIRPα
  • GITR:GITRL
  • CD40:CD40L
  • PD-1/PD-L1/PD-L2
  • CD137:CD137L

 

Today I’d like to focus on the IDO pathway.

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