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tebu-bio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Supplying Discovery Tools

New CryostaX® Rodent Hepatocytes – largest pools available, easy-to-use pellet format

28/08/2018 by Isabelle Nobiron, PhD No Comments

Sekisui XenoTech have announced the addition of Rodent Hepatocytes to their patented CryostaX® product line.

The CryostaX® in vitro drug discovery and preclinical drug development test system is continuously expanding with these new pooled Sprague-Dawley rat hepatocytes  released in July, and pooled CD-1 mouse hepatocytes soon to be launched.

CryostaX® hepatocytes are liver cells that are prepared using a patented process that produces unique cryopreserved cell pellets. This single-freeze preparation process provides greater convenience to researchers, versatile pooling options, and minimizes freeze-thaw injury to the cells, which promotes high viability, cell yield and enzymatic activity for longer-term, consistent test results. What else makes Cryostax a popular choice for researchers?

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Supplying Discovery Tools

Kupffer cells in co-culture models for liver inflammation studies

25/06/2018 by Isabelle Nobiron, PhD No Comments

Kupffer primary cells are macrophages endogenous to the liver which have the ability to modulate hepatic inflammation and injury associated with various pathophysiologies and toxicities. Pro-inflammatory cytokines released by activated Kupffer cells, such as TNF-α and IL-6, are associated with up-regulation of acute-phase response proteins and suppression of CYP enzymes. For new biological entities, particularly immunomodulators, evaluating the potential for Kupffer cell activation is an emerging concept in preclinical development. Kupffer cells are estimated to comprise approximately 4-8% of total liver cell content and approximately 20% of non-parenchymal cells (Raccanelli and Rehermann, 2006).

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ADME-Tox, Cell Sourcing - Cell Culture Technologies, Headlines, Supplying Discovery Tools

Maximise availability& reduce variability in hepatocytes studies

02/05/2018 by Jean-François Têtu, PhD No Comments

ADMEPooled human hepatocytes are a preferred test system in many drug discovery and development applications requiring intact cellular systems for in vitro testing. Intact hepatocytes contain the major hepatic drug-metabolizing enzymes and co-factors required to effectively evaluate the metabolism and potential drug-drug interactions of drug candidates.

Over the last decade, improvements in cryopreservation technologies have made using cryopreserved human hepatocytes more convenient. Pooled cryopreserved hepatocytes reduce the inter-individual differences and polymorphic distribution of liver enzymes. However, it’s crucial to carefully select a pool according to its performance but also the application it is to be used for.

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ADME-Tox

What to do with Microsome Stable, Low-Turnover Compounds

09/04/2018 by Isabelle Nobiron, PhD 2 Comments

In a few forthcoming posts, I’d like to share several short articles published by Dr Chris Bohl of Sekisui Xenotech, a technical expert in the field of ADME-Tox tools and applications. I feel they may be of special interest to researchers working in the field of ADME-Tox studies.

Today, we’ll take a look at compounds that exhibit high metabolic stability in hepatocytes and subcellular fractions (S9, microsomes and cytosol), as these can be a challenge for ADME scientists.

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