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    ADME-Tox
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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Supplying Discovery Tools

New Flipper-TR probes – easily measure membrane tension in cells

25/03/2021 by Frédéric Samazan No Comments

Despite its importance in the regulation of many cellular processes, membrane tension is still complicated to measure. And despite valuable insights, the techniques currently available remain complex and present technical limitations. To overcome these drawbacks, Spirochrome have developed Flipper-TR, the first probes for fluorescence microscopy in the field of mechanobiology, that specifically targets the plasma membrane of cells and reports membrane tension through changes in its fluorescence lifetime.

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Cell Biology and Signalling

Live Cell Imaging – Monitor your cellular events by Fluorescent Microscopy

03/10/2017 by Frédéric Samazan No Comments
Multicolor imaging using HeLa cells expressing Mitochondria-GFP: Lysosomes were stained with AcidiFluor™ ORANGE (ref. GC301) and nucleuses were stained blue with Hoechst33342.

Live Cell Imaging has transformed the way biologists study cellular functions and processes. The observation of dynamic changes provides more insight into the processes happening in a cell, as compared to imaging studies of fixed cells. Goryo Chemical have developed a broad range of innovative Live Cell Imaging fluorescent probes for various applications. Let’s take a closer look…

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Cell Sourcing - Cell Culture Technologies

Microcell arrays – obtain more accurate data from single living cells

17/07/2017 by Frédéric Samazan 3 Comments

Understanding how mammalian cells function requires a dynamic perspective. Recent improvements in our abilities to perform fluorescence microscopy on primary cells, coupled with advances in pipelines for quantifying and extracting data, have made possible a better understanding of the temporal complexity of cell signalling pathway. Due to the heterogeneity seen in both eukaryotic and prokaryotic cell populations, study at the single cell resolution with living cells is currently the best solution to understand the dynamics between environmental conditions and cellular behaviour.

However as living cells don’t stay still, classical imaging and studying methods present some drawbacks for single cell analysis and tracking such as:

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Cell Sourcing - Cell Culture Technologies

3D Cell culture: Innovative cell culture devices for more predictive 3D models

05/04/2017 by Frédéric Samazan No Comments

One of the biggest challenges as a researcher in life sciences, is to obtain proof of concept the more predictive as possible. To help you to reach your objectives, many innovative tools are being developed and new techniques are emerging. In this post, I’d like to essentially focus on two innovative cell culture devices which mimic in-vivo conditions in in-vitro systems, in fields such as 3D cell culture, Microfluidics and oriented cell culture.

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