• Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
  • Facebook
  • LinkedIn
  • Twitter
  • Vimeo
Home
Research areas
    ADME-Tox
    Biomarkers
    Cell Biology and Signalling
    Cell Sourcing - Cell Culture Technologies
    Drug Discovery
    Gene Expression - Molecular Biology
    Stem Cells
    Supplying Discovery Tools
Contact us
Meet the authors
Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Drug Discovery, Gene Expression - Molecular Biology

5 new research tools to perform chromatin and epigenetic analysis

10/07/2014 by Philippe Fixe, PhD No Comments
Nucleosome schematic structure

Nucleosomes are core particles involved in DNA packaging in eukaryotic cells. They affect gene expression levels  by regulating access of DNA to transcription factors and DNA binding proteins. Nucleosome modeling is not static and chaotic. The link between nucleosome dynamics and gene expression modulation still remains a mystery, driving Life Scientists to design clever nucleosome-based in vitro assays such as those we’ll be reviewing here.

Continue reading
News

5 fully funded Epigenetic Grants offered by EpiCypher

01/07/2014 by Philippe Fixe, PhD No Comments
Nucleosome schematic structure

EpiCypher is offering five fully funded EpiTitan™ Histone Peptide Array Screening & Services Grants, for which applications are to be submitted by September 10, 2014. Applications will be reviewed by an independant scientific community.

Epigenetics is the study of heritable changes in phenotype that exhibit no underlying changes in DNA sequence. Over the past several years there has been a significant increase in the number of epigenetic regulators as clinical targets, including Histone Deacetylases (HDAC), Bromodomain Proteins (BET), DOT1L, and EZH2. A number of these targets have FDA-approved drugs, or are in late stage clinical trials, to inhibit their function, demonstrating the adoption of supporting patients with diseases involving epigenetic targets.

Continue reading
Drug Discovery

Histone Peptide Arrays' contribution in Epigenetic studies

12/03/2014 by Philippe Fixe, PhD No Comments
EpiGold™ Histone Peptide Array Data-ECL

EpiGold™ Histone Peptide Array Data-FluorescenceDNA methylation and histone post-translational modifications are key epigenetic factors.

They regulate gene expression by interfering with the chromatin structure and the binding of effector proteins to post-translational modified histones (1).

Several experimental strategies to analyze such binding have recently been designed; histone modified peptide arrays being one of them.

Continue reading

Most popular posts

  • HeLa cells: Origin of this important cell line in life science research
  • From RUO to IVD - the acronym guide to reagents' intended use
  • How to choose the perfect buffer to get a pure, stabilised, functional protein
My Tweets

Privacy & Cookies: This site uses cookies. By continuing to use this website, you agree to their use.
To find out more, including how to control cookies, see here: Cookie Policy

Copyright © 2018 - tebu-bio - visit our main website at tebu-bio.com

 

Loading Comments...