Which hepatocytes should you choose for your ADME Studies?

What are hepatocytes and why are they important?

Hepatocytes are the functional parenchymal cell of the liver. They are important for ADME/DMPK scientists because they’re the cells that carry out the bulk of metabolism for xenobiotic compounds and play a major role in detoxifying the body. Understanding how these functions affect your compound is essential in preclinical drug development.

Hepatocytes make up about 80% of the liver’s volume, but only represent approximately 60% of the total cell population. This basically means that they’re big, and because of their size and other physical properties, we can take advantage of these characteristics to purify them away from other cell types in the liver.

Many researchers are facing the challenges of mRNA delivery, through the body into the cytoplasm of cells. In this post, we invite you to discover some useful and efficient solutions to improve and control all the steps of your mRNA delivery project.

Propelled into the spotlight by the COVID-19 pandemic, mRNA has become a biological entity of great interest in drug discovery – yet mRNA vaccines are just the promising beginning, leading to more and more discoveries and applications. mRNA demonstrates high potential to cure numerous other diseases, as we invite you to discover in this post – let’s take a look at a number of other mRNA based applications with active R&D, establishing mRNA beyond a current trend.

mRNA vaccines are developing very quickly with dozens of ongoing clinical trials against cancers or infectious diseases (e.g. HIV or more recently SARS-Cov-2). Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. Nevertheless, researchers are now considering using messenger RNA (mRNA) technologies for the development of prophylactic and therapeutic vaccines.