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Research areas
    ADME-Tox
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    Cell Sourcing - Cell Culture Technologies
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    Gene Expression - Molecular Biology
    Stem Cells
    Supplying Discovery Tools
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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Biomarkers, Supplying Discovery Tools

How to monitor inflammatory cytokines in anti-COVID drug discovery

08/04/2020 by Philippe Fixe, PhD No Comments
Inflammatory Cytokine Array and ELISA Services tebu-bio

The close relation between Severe Acute Respiratory Syndrome (SARS), unpaired adaptive immune responses and overexpression of inflammatory cytokines has been described more than a decade ago (1, 2).
More recently, the notion of “cytokine storm” or “cytokine release syndrome” has been used by Life Scientists when they have monitored the expression level dynamics of cytokines in the sera of COVID-19 patients with acute lung damages and respiratory distress. (3)

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Supplying Discovery Tools

Want to know more about your Biologics?

13/09/2019 by Isabelle Nobiron, PhD No Comments

In new drug development pipelines, there is an increasing trend to switch from “small” to “large” molecules (also known as biologics). While the FDA guidance was quite specific with their recommendations for small molecules ADME-Tox studies, there is not much currently published for these large molecules.

The Japanese PDMA guidelines 2019 issue refers to some specificity regarding their internalization and degradation pathway. They are also well known to be prone to trigger cytokine release. The so called “cytokine storm” is one of the major toxicity events to be feared.

To support R&D projects around Biologics development, I have illustrated in this post what tebu-bio can offer in terms of reagents and services, including tools to monitor cytokine release (blood derivatives and cytokine multiplex assays), and reagents to help decipher their mechanism of action and catabolism.

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Supplying Discovery Tools

Protein multiplex profiling as simple as western blot

17/04/2018 by Isabelle Nobiron, PhD No Comments

In one of my previous posts, I wrote about high density glass slide antibody arrays services.

Here, I’d like to focus on another antibody microarray product line, the C-series from Raybiotech, based on a membrane antibody array technology. Similar to western blotting – therefore very easy to process – they are suitable to most research laboratories for targeted protein profiling.

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Supplying Discovery Tools

How do you choose the best ELISA test for your project ?

09/11/2017 by Isabelle Nobiron, PhD No Comments

There are many, many ELISA tests out there to choose from, and making the best selection can sometimes be a bit daunting. In this post, let’s take a look at the key points to keep in mind.

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