In vivo monitoring of tumor growth and metastasis provides a powerful means for studying cancer properties and development of effective therapies. Mouse models created with tumor xenografts, resulting from subcutaneous or tail vein injection of cells, have long been used for such purposes. However, without a convenient means to visualize cancer progression in these animals, invasive surgical procedures are required in order to estimate the size and weight of primary and metastatic tumors, and cannot be used for early stages in tumor development. Surgery often requires sacrificing the animals, leading to the need for large numbers of individuals and increasing the cost and risk of sampling errors.
GeneCopoeia has recently announced the introduction of pre-made cancer cell lines labeled with GFP, and pre-made cancer cell lines dual-labeled with luciferase and GFP. A new powerful and sensitive mathods to follow tumor growth & metastasis in vivo!