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    ADME-Tox
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tebu-bio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Supplying Discovery Tools

Stauprimide inhibits c-myc transcription in cancer cells

04/04/2017 by Philippe Fixe, PhD No Comments
Activators, inhibitors and small molecules screening and enzyme profiling

Stauprimide is known to prime Embryonic Stem Cells (ESC) by targeting the c-Myc-activating transcription factor NME2. Its mechanism of action is linked to the inhibition of the nuclear localization of NME2 leading to the downregulation of the transcription of the c-myc oncogene.

In a recent study, Bouvard C. et al. evidenced that Stauprimide’s mechanism of action could also be used to pharmacologically targetc-myc transcription in cancers.

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Cell Biology and Signalling

3 new mitochondrial research reagents

27/10/2016 by Philippe Fixe, PhD 1 Comment
Mitochondria and mitochondrial research

Research tools aimed at exploring mitochondria are becoming more and more popular and cover multiple experimental applications. They go from primary antibodies validated for immuno-assays (see “10 Mitochondrial marker antibodies“) to fluorescent probes for mitochondria-related events monitor in living-cells (e.g. MitoPeDPP for live cell imaging, mitophagy or singlet Oxygen (1O2) detection…). Here I’d like to introduce 3 new molecules developed by Focus Biomolecules to further decipher mitochondrial biology.

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News

2 breakthroughs in 2015 for treating cataracts

06/01/2016 by Philippe Fixe, PhD No Comments
Immunohistochemical analysis of paraffin-embedded human hepatoma to detect Lanosterol Synthase with anti LSS (GTX105363)

The year 2015 was full of significant publications in the field of ophthalmology. Here’s a snapshot of 2 “proof-of-concept” studies suggesting that “Sterols” could be promising approaches to treat cataract.

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Drug Discovery

6 active compounds to rediscover rare bacterial metabolites

11/12/2015 by Philippe Fixe, PhD 2 Comments
Activators, inhibitors and small molecules screening and enzyme profiling

6 active compounds to rediscover rare bacterial metabolitesMicrobial metabolites are a source of unequalled elements for in vitro assays. Sometimes  neglected, these active molecules naturally provide a large spectrum of structural diversity for Drug discovery and antibiotics development programs. In this post, 6 metabolites and their respective properties are highlighted with the hope of refreshing our minds, a little bit, of the importance of such molecules in innovative research discovery.

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