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New, more sensitive monoclonal based Allopregnanolone kit for AD research

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Progesterone derived Allopregnanolone (ALLO) is an extensively studied neurosteroid that has been shown to be involved in neurodegenerative diseases, including Alzheimer’s, Parkinson’s disease, and multiple sclerosis. It is also linked to neuroinflammatory processes through a beneficial action on pro-inflammatory cytokines.

Allopregnanolone detection kits based on polyclonal antibodies were already available through Arbor Assays (K044-H and K044-C), a specialist of immunassay kits, with a special focus on inflammation and reproduction targets.

A new Allopregnanolone EIA kit has just been released, based on a monoclonal antibody (K061-H1). In addition to the supply stability offered by the monoclonal antibodies, this new kit is more sensitive than the original one, it requires smaller sample volumes and provides increased signal. It also has a more favorable cross reactivity profile: [Read more…]

2 new validated anti-PGP 9.5 antibodies for neuroscience research

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Protein Gene Product 9.5 (PGP 9.5) is an abundant cytoplasmic neuron and neuroendocrine-cell specific protein. Over the years, this deubiquitinating enzyme (a.k.a. Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1)) has become an accepted biomarker for neurons and cells of the diffuse neuroendocrine system (DNES) but also when studying neurodegenerative disorders (e.g. Alzheimer’s and Parkinson’s diseases) and cancers.

Research antibodies specific for PGP9.5 / UCH-L1 stain neuronal cell bodies and axons in the central and peripheral nervous systems, small nerve fibres in nerve tissue, neuroendocrine cells in the pituitary, thyroid pancreas, and also tumours of the DNES.

In this context, Cedarlane just release 2 new anti-PGP9.5 / UCHL1 rabbit polyclonal antibodies fully validated & guaranteed for IHC analysis of Paraffin Embedded Sections, IF and WB applications on Human, Rat and Mouse tissues. [Read more…]

Unlimited sources of neural cells mimicking CNS disorders for in vitro bioassays

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Access to neural cellular models for in vitro Neuroscience research enters into a new era.

XCell Science, experts in cellular and genome engineering, provide genetically modified cellular models differentiated from Human induced Pluripotent Stem Cell (iPSC) lines. tebu-bio bring its scientific and logistics skills to deliver in Europe these high-quality and characterized neural cell derivatives for R&D, drug discovery, toxicology and regenerative medicine approaches.

Unlimited sources of biologically relevant functional neural cells

Proprietary high-efficiency protocols allow the directed differentiation of these iPS lines into a variety of functional neural cells, such as:A large collection of neural cells (XCell Science - tebu-bio)

  • Neural Stem Cells (NSC),
  • Neurons,
  • Dopaminergic neurons,
  • Astrocytes.

Disease-specific knock-out isogenic neural cell lines

tebu-bio’s experts are pleased to introduce a collection of isogenic knock-out iPSC lines mimicking genetic defects identified in CNS disorders (Parkinson’s and Alzheimer’s diseases, Autism, Schizophrenia and Amyotrophic Lateral Sclerosis (ALS)):

  • BDNF-/-: Homozygous knockout of the BDNF gene,

    Dopa Neural Cells (XCell Science by tebu-bio)

    Expression of TH in Ready-to-use XCell DOPA cells prolonged cultured in DOPA medium.

  • APOE-/-: Homozygous knockout of the APOE gene,
  • DISC1-/-: Homozygous knockout of the DISC1 gene,
  • CNTNAP2-/-: Homozygous knockout of the CNTNAP2 gene,
  • SOD1-/-: Homozygous knockout of the SOD1 gene,
  • Park2-/-: Homozygous knockout of the Park2 gene,
  • Park7-/-: Homozygous knockout of the Park7 gene.

Want to know more about these unlimited iPSC-derived neural cellular models ?

XCell Science logo by tebu-bio

XCell Science by tebu-bio

 

Be among the first to receive the XCell Science launch pack by tebu-bio to optimise your in vitro CNS-specific cellular models.

Sign up now!

 

iPSC-derived Neural cells characterization - XCell Science by tebu-bio

iPSC-derived Neural cells characterization – XCell Science by tebu-bio

Related posts regarding CNS and Stem cell studies:

 

3 unique Amyloid Beta peptide (Aß) research tools to boost Alzheimer's Disease research

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Alzheimer’s Disease (AD) is a type of dementia which induces progressive and non-reversible brain disorders (memory and cognitive loss, thinking and behavior changes…). AD ultimately ends in severe mental dysfunction due to neuronal death and breakdown of neural connections. The majority of people with AD are 65+ (late-onset AD). Even if age is one of the greatest risk factors, >5% of AD patients are in their 40s or 50s (early onset AD) making genes and heredityother important AD risk factors (1-4). [Read more…]