Actin binding proteins (ABPs) have a wide variety of functions in regulating the cellular function of actin. They control G-actin polymerization but also drive actin filaments severing and cross-linking to form complex cytoskeleton networks. Here, I’d like to review the recent research reagents aimed at studying actin regulation.
Actin dynamics are constantly controlled by numerous types of physiological elements (Actin Binding Proteins, Calcium levels, pH, extracellular stimuli, intracellular signaling pathways…). Understanding and deciphering cytoskeleton actin dynamics and their molecular modulation is challenging. Nowadays, fluorescent Atto-actin conjugates are available for these purposes. Let’s take a moment to review actin research tools for actin filament analysis.
Actin filaments are essential for cytoskeleton functions (cell morphology, endocytosis and trafficking, contractility, motility…). In eukaryotic cells, polymerization and depolymerization of actin filaments together with their organization in higher magnitude actin-based superstructures and their complex dynamic properties are regulated by Actin-Binding Proteins (ABPs). Here, let’s review the ABPs recently released for cytoskeleton molecular modeling studies.
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