Actin binding proteins (ABPs) have a wide variety of functions in regulating the cellular function of actin. They control G-actin polymerization but also drive actin filaments severing and cross-linking to form complex cytoskeleton networks. Here, I’d like to review the recent research reagents aimed at studying actin regulation.
Actin filaments are essential for cytoskeleton functions (cell morphology, endocytosis and trafficking, contractility, motility…). In eukaryotic cells, polymerization and depolymerization of actin filaments together with their organization in higher magnitude actin-based superstructures and their complex dynamic properties are regulated by Actin-Binding Proteins (ABPs). Here, let’s review the ABPs recently released for cytoskeleton molecular modeling studies.
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