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3D cell culture: discover the new VitroGel™ 3D Hydrogel system

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VitroGel™ 3D (TheWell Bioscience) is an animal origin-free hydrogel system closely mimicking the natural extracellular matrix (ECM) environment. Cells grown in this 3D hydrogel possess morphologies and cellular behaviours close to their natural state making it ideal for 3D cell culture.
Therefore, VitroGel™ 3D fits perfectly with our “cellphy” offer, providing life scientists with reagents and laboratory services mimicking the physiological environment of the Human body in vitro, for more physiologically relevant experimental data.
You can choose between two:
  1. VitroGel™ 3D (cat. nr TWG001): an animal origin-free hydrogel system mimicking the natural ECM, ideal option for floating cell lines.
  2. VitroGel™ 3D-RGD (cat. nr TWG002): RGD peptide modified hydrogel of VitroGel 3D promoting cell attachment and cell-matrix interactions for 3D-culture and 2D-coating (invasion/migration, chemiotaxis…). Best solution for adhesion cell lines. [Read more…]

AIM Biochips – 3D cell culture platform for Immunotherapy and T Cell therapy studies

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As mentioned in a previous post the DAX Biochips from AIM Biotech are an innovative and versatile microfluidic platform, allowing researchers to more easily develop 3D cell culture models, to work as close as possible to what occurs in the human body, but under in-vitro conditions.

Due to its innovative structure (as seen in this general AIM Chips flyer), a broad range of applications have already been validated on this model (Cellular Migration-Invasion Analysis / Angiogenesis studies / Metstasis Modeling System), but what’s new is that now Immunotherapy and T-Cell Therapy studies can be performed on this technology.

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AACR2018 – tebu-bio presents “Time-lapse analysis of drug response and invasive capacity…”

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This year again, we were pleased to attend the Annual meeting of the AACR (American Association for Cancer Research), which took place in Chicago, USA earlier this month.

Dora Sabino PhD of tebu-bio at the AACR2018 Poster Session
Dora Sabino PhD of tebu-bio at the AACR2018 Poster Session
Dora Sabino PhD of tebu-bio at the AACR2018 Poster Session

Dora Sabino Ph.D. (3D Cell Culture Project Manager, tebu-bio) presented a poster covering a physiologically relevant study on 3D colon cancer models in microfluidic chips:

“Time-lapse analysis of drug response and invasive capacity using patient-derived and CRC microfluidic 3D cancer models under oxygen controlled conditions”

Extract from "Time-lapse analysis of drug response and invasive capacity using patient-derived and CRC microfluidic 3D cancer models under oxygen controlled conditions"

Extract from tebu-bio’s poster “Time-lapse analysis of drug response and invasive capacity using patient-derived and CRC microfluidic 3D cancer models under oxygen controlled conditions”

Download your copy of the poster here and learn more about tebu-bio’s laboratory outsourcing solutions.

Four new validated 3D Tissue models for more accurate in vivo-like data

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In the field of Drug Development, 3D cell culture models such as spheroids or organoids currently appear as one of the best solutions to obtain accurate and physiological in vitro data, closest to what occurs in the human body. These models are the perfect intermediary between “less realistic” classical in vitro static screening well plates, and animal models which, although more relevant, are much more complicated to set up, and are time consuming. [Read more…]

3D cell culture Biochip – versatile for more physiological applications

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By mimicking in-vivo environments, 3D cell culture models appear nowadays as the best in-vitro study model to work in an in-vivo like study model and to obtain more physiologically relevant data and proof of concept as close as possible to “a clinical context” (aka the “near-human” approach).

3D cell culture chip - AIM Biotech tebu-bio - near-human approaches

3D cell culture chip – AIM Biotech tebu-bio – near-human approaches

To accompany researchers along this way, there are several innovative cell culture devices (available in Europe through tebu-bio), and more specifically a modular microfluidic platform for 3D cell culture with the capability to monitor complex biological systems dynamics in response to tuned microenvironment: the 3D Cell culture chip (Aim Biotech) [Read more…]

Pluripotent Stem Cells and iPSC Research: Quality and Innovative Products

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Induced pluripotent stem cells (iPSC) - tebu-bio

Since the discovery of reprogramming factors in 2006 and the boom of CRISPR gene editing strategies, induced pluripotent stem cells (iPSC) have emerged as new cellular models. The development of 3D cell culture technologies has also contributed to the generation of induced Pluripotent Stem Cell (iPSC) derived cells, with unique applications from patient-specific drug responses testing, to regenerative medicine. I would like to introduce in this post a selection of reagents in this domain, a combination of both routine and innovative quality reagents, that I consider as bringing something extra to your stem cell research projects.

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3D Cell culture: Innovative cell culture devices for more predictive 3D models

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One of the biggest challenges as a researcher in life sciences, is to obtain proof of concept the more predictive as possible. To help you to reach your objectives, many innovative tools are being developed and new techniques are emerging. In this post, I’d like to essentially focus on two innovative cell culture devices which mimic in-vivo conditions in in-vitro systems, in fields such as 3D cell culture, Microfluidics and oriented cell culture. [Read more…]