Due to their ability to simulate the characteristics of most soft tissues and natural scaffolds, hydrogels are now an attractive material for developing synthetic Extracellular Matrix (ECM) analogs.

Recently, the VitroGel™ hydrogels have been designed for researchers willing to fully master the characteristics of the synthetic ECM to be used with their 3D / 2D cell cultures. In this post, we will review the main benefits of the recently released VitroGel™ solutions.

When compared to 2D conventional cell culture systems, experimental data obtained with 3D cell culture models have been shown in many instances to be more biologically relevant, closer to clinical conditions (eg. predictive assays/preclinical therapeutic testing). In this context, tebu-bio laboratories have developed a spheroid platform with a selection of downstream analysis applications such as live cell imaging, microfluidic and physioxia culture conditions or downstream multiplex biomarker quantification, among others. If you need more physiologically relevant models for your study, but you don’t have access to the technologies or haven’t the time to spend on setting up spheroid cultures in your own laboratories, read on to see what tebu-bio laboratories can generate for you in terms of data.

As mentioned in a previous post the DAX Biochips from AIM Biotech are an innovative and versatile microfluidic platform, allowing researchers to more easily develop 3D cell culture models, to work as close as possible to what occurs in the human body, but under in-vitro conditions.

Due to its innovative structure (as seen in this general AIM Chips flyer), a broad range of applications have already been validated on this model (Cellular Migration-Invasion Analysis / Angiogenesis studies / Metstasis Modeling System), but what’s new is that now Immunotherapy and T-Cell Therapy studies can be performed on this technology.

This year again, we were pleased to attend the Annual meeting of the AACR (American Association for Cancer Research), which took place in Chicago, USA earlier this month.

Dora Sabino Ph.D. (3D Cell Culture Project Manager, tebu-bio) presented a poster covering a physiologically relevant study on 3D colon cancer models in microfluidic chips:

“Time-lapse analysis of drug response and invasive capacity using patient-derived and CRC microfluidic 3D cancer models under oxygen controlled conditions”

Download your copy of the poster here and learn more about tebu-bio’s laboratory outsourcing solutions.