Resveratrol – recent discoveries in pancreatic cancer research

Resveratrol structure

Resveratrol, a phenolic antioxidant with anti-ageing effects and properties in cancer therapy

Resveratrol (RSV) is a bioactive small molecule known to have antioxidant properties. RSV is a SIRT1 activator and ameliorates ageing-related phenotypes through cAMP phosphodiesterase inhibition.

But RSV has many other properties, especially in cancer research.Resveratrol structure

Yang et al. have recently published  a paper in the Journal of Cancer Research and Clinical Oncology about the potential benefits of the Resveratrol (RSV) in pancreatic cancer therapy (1). In this article, the authors highlighted the dual role of RSV in pancreatic cancer cells (Bax mediated cancer suppressor vs. VEGF-B-mediated cancer activator ). They finally suggested that the combination of RSV with a therapeutic inhibitor of VEGF-B could be promising for clinical pancreatic therapy.

(1) Yang et al.Resveratrol plays dual roles in pancreatic cancer cells” (March 2014) Journal of Cancer Research and Clinical Oncology – DOI10.1007/s00432-014-1624-4

Want to find high quality, bioactive small molecules for R&D research projects?

Many sources of active compounds exist on the market. One of the most serious is Focus Biomolecules. Created by former BIOMOL scientists, Focus Biomolecules offer a large and constantly expanding portfolio of cutting edge small molecule reagents (including RSV) with unique scientific expertise in research and drug discovery.

Written by Philippe Fixe, PhD
Philippe Fixe is a former Marketing Manager at tebu-bio, passionate about innovation and R&D in Life sciences, Biotechnology, Medical research, Drug discovery, and also a keen photographer.