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    ADME-Tox
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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Supplying Discovery Tools

COVID-19: relevant cell culture models

30/04/2020 by Isabelle Nobiron, PhD No Comments

One of the challenges in respiratory research in general, and for COVID-19 related projects in particular, is to have access to relevant in vitro cell culture models. Human lung epithelium models are currently being tested as a platform for COVID-19 research and several cell types susceptible to SARS-CoV infection have already been identified. In this post, I’ll introduce lung primary cell models you may find useful, as well as other cell types that have been reported as involved in COVID-19 infections and the multiple severe associated syndromes.

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Supplying Discovery Tools

CleanCap: The new capping standard for self-amplifying mRNA

by Dimitri Szymczak, PhD 2 Comments

Advances in mRNA Vaccines for Infectious Diseases

It is now admitted that mRNA vaccines provide a safe and long-lasting immune response in humans. Since capping of the mRNA is involved in the protein production into the cells, the capping technologies are of great interest for the development of prophylactic and therapeutic vaccines. In this post, I’ll focus on the CleanCap reagents (Trilink BioTechnologies), and notably the CleanCap AU for the self-amplifying mRNA, as well as their benefits, especially for vaccine approaches against pathogens (including the SARS-CoV-2).

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Drug Discovery

How are mRNA vaccines changing drug discovery?

24/04/2020 by Dimitri Szymczak, PhD No Comments

mRNA vaccines are developing very quickly with dozens of ongoing clinical trials against cancers or infectious diseases (e.g. HIV or more recently SARS-Cov-2). Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. Nevertheless, researchers are now considering using messenger RNA (mRNA) technologies for the development of prophylactic and therapeutic vaccines.

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Supplying Discovery Tools

Immunoassay development: reliable sources of quality reagents

17/04/2020 by Isabelle Nobiron, PhD No Comments

We understand how crucial it is to have access to sustainable, quality sources of reagents when developing and/or producing the same immunoassays over long periods of times. Over the years, we’ve established partnerships with a number of experienced and renowned manufacturers, whose high-quality reagents we provide to researchers throughout the whole of Europe.

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