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    ADME-Tox
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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Supplying Discovery Tools

Analysis tool for direct and sandwich ELISA – convenient and reliable

11/07/2017 by Dimitri Szymczak, PhD No Comments

Many ELISA kits – one analysis tool

ELISA test analysis tool by tebu-bioAnalyte quantification (in pg/ml or ng/ml) such as IL-6, TNFalpha and numerous other proteins is conveniently performed with immunoassays called ELISA kits. At tebu-bio, we not only provide more than 10 000 ELISA kits but we also support researchers through our techserv team who are on-hand to suggest the best kits and to answer any questions.

Being part of that team, I have noticed a number of often asked questions that can be resumed in one : What is the best method for data analysis?

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Supplying Discovery Tools

Cell Signalling: Ras-Raf-MEK-ERK pathway research tools

07/07/2017 by Isabelle Nobiron, PhD No Comments

The Ras-Raf-MEK-ERK Pathway is an important cell signalling route with many implications for cancer biology and therapeutic development. Dis-regulation of some of this pathway’s proteins expression and phosphorylation status are observed in about one-third of all human cancers. Access to specific tools to study this pathway is essential to a better understanding of its role in cancer for novel drug development. If you are working on this topic, you’ll be interested in taking a look at the range of reagents on offer for a wide variety of applications.

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Gene Expression - Molecular Biology

Optimizing the CAS9 messenger RNA for vector-free gene editing

28/06/2017 by Dimitri Szymczak, PhD No Comments

Sequence engineering and chemical modification of CAS9 mRNA

Cas9 Western Blot in CD34+ cells - Trilink poster "“Maximizing Translation of Cas9 mRNA Therapeutics by Sequence Engineering and Chemical Modification”"

Extract from poster “Maximizing Translation of Cas9 mRNA Therapeutics by Sequence Engineering and Chemical Modification”.

For transgenesis and therapeutic perspectives, vector-free delivery of the CAS9 for gene editing is highly preferable. It avoids the risk of hitting the genome due to the vector integration. Directly using CAS9 mRNA is a top option.

Furthermore, as a new promising class of therapeutic biologics, messenger RNA are the subject of numerous studies.

This year, Matthew Porteus’s and Trilink’s teams revealed key and practical results at the ASGC with a poster you can download below.

Notably, there is a large screen of the mRNA CAS9 modifications based on the indel formation. This interesting comparison includes also CAS9 RNP and reveals the high performance of the CleanCap U-depleted 5-moU CAS9 mRNA. We can also note that for the CleanCap CAS9 mRNA HPLC purification is not required.

“Maximizing Translation of Cas9 mRNA Therapeutics by Sequence Engineering and Chemical Modification”
Download your copy of the poster here.

 


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Travel Grant Winners, where have they been to?

27/06/2017 by Sara Pierre No Comments

tebu-bio’s latest Travel Grant draw took place on June 16th, and saw six more researchers win 400 Euros each towards attending the meeting of their choice.

Here’s some news from two of our previous winners (in October 2016 and February 2017), who were happy to share these pictures from the same meeting they both attended!

27th European Congress of Clinical Microbiology and Infectious Diseases – Vienna, Austria –  April 2017

Dr Giuliana Banche of the University of Torino (Italy) presenting her research.
Dr Giuliana Banche of the University of Torino (Italy) presenting her research.
2016-10 - Giuliana Banche 2
2016-10 - Giuliana Banche 3
Beatriz Rojo of the CIBIR (Spain), presenting her research.
Beatriz Rojo of the CIBIR (Spain), presenting her research.
2017-02 - Beatriz Rojo-Bezares

Interested in winning 400 euros for your next meeting?

tebu-bio’s fourth and final draw for 2017 will take place in October, applications are now open and can be uploaded online here.

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