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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Cell Biology and Signalling

Cell signalling: How to easily detect mono- and poly-Ub target proteins

26/02/2018 by Philippe Fixe, PhD No Comments
Recently, a new series of ready-to-use reagents for studying post-translation modifications (PTMs) of your proteins of interest have been released by Cytoskeleton, Inc. To illustrate the advantages of these research tools, this post is focuses on ubiquitination detection, which is known to be an important event in cell signalling.
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ADME-Tox

Recombinant CYP Bactosomes: versatile formats for many ADME applications

22/02/2018 by Isabelle Nobiron, PhD No Comments

Recombinant CYPs are commonly used in ADME-Tox studies as in vitro tools, mostly for reaction phenotyping, enzyme inhibition screening, clearance and metabolite ID.

“Research has shown that rCYPs expressed in E. coli (Bactosomes) showed greater enzymatic activity compared with the equivalent enzymes expressed in insect cells (Supersomes). Similarly, most Bactosomes show greater turnover numbers when compared with the equivalent Supersomes. These results demonstrate that human rCYPs expressed in E. coli are frequently more active than the corresponding rCYPs expressed in insect cells» says Michael Voice from CYPEX.

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Biomarkers

Cell signalling: Where to find multiplex arrays for glycobiology studies

21/02/2018 by Philippe Fixe, PhD No Comments
Glycan 300 Array RayBio fluorescent scan

How do you detect 300 specific glycan binding proteins in one experiment? Well, in this post we’ll answer this question by introducing the new Glycan Array, developed by RayBiotech for your cell signalling studies.

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Supplying Discovery Tools

How to easily screen adenosine A2AR agonists and antagonists

20/02/2018 by Philippe Fixe, PhD No Comments
Adenosine A2A Receptor Functional Recombinant Stable Cell Line 79381 BPS tebu-bio

Recently, BPS Bioscience have released a new Adenosine A2A Receptor (A2AR / ADORA2A) Functional Recombinant Cell Line for screening A2AR agonists and antagonists. An excellent means to efficiently evaluate the Adenosine cell signaling pathway known to be deeply involved in all phases of inflammation and immune responses with potential interest in immunotherapies.

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