The cGAS-cGAMP-STING cell signalling pathway plays a critical role in antiviral and antitumor immunity as well as mediating autoimmune responses. Dysregulation or aberrant activation of the pathway by self-DNA has emerged as an underlying cause of tumorigenesis and autoimmune disorders. As the critical role of cyclic dinucleotides in pathophysiology continues to emerge, new tools to study these signaling pathways are being developed. This post introduces the latest ELISA released on the market.

tebu-bio is pleased to announce their new partnership for a European distribution of Novabiosis, a US based manufacturer providing cryopreserved primary human cells for the biotechnology, pharmaceutical and medical research fields. Their focus is on Kidney, Intestine, Lung and Liver tissues. They have developed multiple cell types for each organ, an asset for co-culture studies or 3D models development.

Now that the novel coronavirus (2019-nCoV or COVID-19) outbreak has been declared a “public health emergency of international concern” by the WHO, scientists worldwide are being pressured to develop a treatment. The first step of research projects focussing on this virus is to identify robust anti-COVID antibodies.

Some antibodies developed for the 2002 SARS strain present opportunities for immediate deployment while others have been recently made available to the research community. In this post, you’ll find a selection of the most sought after anti-COVID research antibodies.

Chromatin profiling assays enable the mapping of protein-DNA interactions that influence chromatin modeling and gene expression.
Over the years, Chromatin ImmunoPrecipitation (ChIP) assays became the gold-standard for studying transcription factor–DNA binding interactions, nucleosome dynamics, and epigenetics (ex. histone post-translational modifications (PTMs)). This post aims at introducing the latest evolution of ChIP assays: CUTANA CUT&RUN and ChIC assays.

Over the last years, ChIP experts express the need for more sensitivity, faster protocols, and more reproducible results (and ideally starting from less starting cellular material). These expectations led to the emergence of new experimental antibody-based experimental approaches like Chromatin ImmunoCleavage (ChIC) assays, and Cleavage Under Targets and Release Using Nuclease (CUT&RUN) methods.