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Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
ADME-Tox

DDI studies: New TransiPort cells for OATP1A2 and OATP2B1 transporters

01/06/2018 by Isabelle Nobiron, PhD No Comments

Membrane transporters can have clinically relevant effects on the pharmacokinetics and pharmacodynamics of a drug in various organs and tissues by controlling its absorption, distribution and elimination. Together with metabolizing enzymes, they can drive a drug’s pharmacological action, as well as a drug can modulate transporter expression or activity, hence the importance of evaluating transporter-mediated drug-drug interactions recommended by the FDA guidelines. Genomembrane have developed transiently expressing ready-to-use cells to study FDA approved transporters (TransiPort). I had described this product range and their unique features in a previous post. I would like to introduce in this one 2 newly released cells overexpressing OATP1A2 and OATP2B1 transporters.

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ADME-Tox

NADPH RapidStart regeneration system for long-term metabolism

30/05/2018 by Isabelle Nobiron, PhD No Comments
Drug discovery

RapidStart stabilityNADPH is a critical cofactor supporting numerous biochemical reactions. In ADME-Tox studies, NAD(P)H regeneration is strongly recommended when using drug metabolizing enzymes (ex. Cytochrome P450 (CYP), Flavin-containing MonoOxygenases (FMO)), Recombinant CYPs (incl. bactosomes) or cellular fractions (Microsomes, S9).  Currently, the most simple and cost-effective way to regenerate the NAD(P)H in situ and enzymatically is to use the commercially-available RapidStart™ NADPH Regenerating System (Xenotech-Sekisui).

RapidStart uses an enzymatic reaction that changes NADP to NADPH, which is then oxidized by CYPs back to NADP, and the cycle continues…

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News

EpiCypher2018 – Biological and Clinical Frontiers in Epigenetics

28/05/2018 by Sara Pierre No Comments

Following the success of the previous EpiCypher meetings, we’re pleased to announce this year’s meeting by one of our partners EpiCypher.

EpiCypher2018: Biological and Clinical Frontiers in Epigenetics will feature keynote addresses by Dr. C. David Allis and Dr. Kristian Helin.

Dr. Allis is the Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology and Epigenetics at The Rockefeller University. Dr. Helin is a Professor at the University of Copenhagen and the director of the Danish National Research Foundation’s Centre for Epigenetics.

The plenary session talks will cover broad aspects of epigenetics and chromatin biology, ranging from basic molecular mechanisms to therapeutic efforts. There will be discussions around the elucidation of novel mechanisms, new tools, and other breaking topics in epigenetics and chromatin research.

Learn more about the meeting – download the flyer here.

Supplying Discovery Tools

New: QuicGSH3.0 – a fluorescent probe to quantify intracellular glutathione

25/05/2018 by Frédéric Samazan No Comments

Glutathione (GSH) is a tri-peptide (Glutamic acid, Cystein and Glycine) present in cells, showing an antioxidant effect allowing the reduction and the removal of Reactive Oxygen Species (ROS) and Peroxide from the cell. The new QuicGSHS3.0 probe from Goryo Chemicals will allow you to easily quantify intracellular concentration of GSH by Fluorescent Live cell Imaging.

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