mRNA Reprogramming

In 2010, a method for integration-free reprogramming by transfecting modified mRNA reprogramming factors was published (1, 2). The use of mRNA to induce reprogramming of somatic cells overcomes the inherent problems incurred by introducing viral vectors and/or integrating DNA to target cells. mRNA reprogramming factors are titratable and controllable with regards to the ratios, concentrations, and timing of factor expression. The mRNA reprogramming system also poses none of the biosafety risks surrounding viral and DNA-based systems.

Here is a photo sent by one of our February Travel Grants Winners !

He is just back from the ConGen meeting near Uppsala in Sweden. His grant helped him pay for the travel expenses.

The Institut Pasteur (Paris, France) announces an international call for candidates wishing to establish independent research groups as a part of the Revive Laboratory of Excellence (LabEx) programme on “Stem Cells and Regenerative Biology and Medicine”.

• Further information: Young Group Leader Position in Stem Cell Biology
• Application deadline: May 31, 2014
• Coordinator of the Revive programme: Shahragim Tajbakhsh (Institut Pasteur, France)

It is widely accepted that data obtained from primary cells is not only desired, but, most relevant when trying to study physiological interactions. Experimentation in primary cells allows a deeper and more physiologically relevant view into the cellular function of proteins and enzymes that will allow the design of more specific drugs with meaningful and specific targets.