Low oxygen tension, or Hypoxia, regulates numerous cellular and tissular functions. In cancer research, hypoxia is a key regulator of tumor development, aggressiveness and therapy resistance by acting on malignant cells and their microenvironment. Hypoxia is also involved in age-related diseases and acts through intracellular and intercellular cascade of events (exosomes, paracrine loops, angiogenesis…) (1-2).

DNA methylation and histone post-translational modifications are key epigenetic factors.

They regulate gene expression by interfering with the chromatin structure and the binding of effector proteins to post-translational modified histones (1).

Several experimental strategies to analyze such binding have recently been designed; histone modified peptide arrays being one of them.

Resveratrol, a phenolic antioxidant with anti-ageing effects and properties in cancer therapy

Resveratrol (RSV) is a bioactive small molecule known to have antioxidant properties. RSV is a SIRT1 activator and ameliorates ageing-related phenotypes through cAMP phosphodiesterase inhibition.

See it on Scoop.it – Biotechnology & Medical research

Brain cancer stem cells from human brain cancer tissue  (Source: Nikon Small World)

IMAGE OF DISTINCTION – 2013 PHOTOMICROGRAPHY COMPETITION
Dr. Biplab Dasgupta, Jane Anderson, Shabnam Pooya, Mariko DeWire & Lili Miles Cincinnati Children’s Hospital and Medical Center (Cincinnati, Ohio, USA).

Technique: Immunofluorescence (200 x)