• Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
  • Facebook
  • LinkedIn
  • Twitter
  • Vimeo
Home
Research areas
    ADME-Tox
    Biomarkers
    Cell Biology and Signalling
    Cell Sourcing - Cell Culture Technologies
    Drug Discovery
    Gene Expression - Molecular Biology
    Stem Cells
    Supplying Discovery Tools
Contact us
Meet the authors
Tebubio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
ADME-Tox

Fully licensed SLC cell lines for FDA and EMA recommended transporters

10/10/2019 by Isabelle Nobiron, PhD No Comments

In a previous post, we introduced our Ready-to-use cellular models for SLC assays by GenoMembrane.

These cell lines transiently express the current FDA and EMA recommended SLC drug transporters (eg. OCT1 and OCT2; OAT1 and OAT3; MATE1; MAT2K…). Conditioned as cryopreserved format, they provide flexibility for experimental planning and can be assayed in just 2 days.

Continue reading
Supplying Discovery Tools

Accelerate your Biomarker discovery with High Density arrays

01/10/2019 by Isabelle Nobiron, PhD No Comments

While Raybiotech recently released their 2000 target antibody array, a publication from “The Scientist” highlighted the benefit of these High-density multiplexed technology in biomarker discovery. As a perfect complement to traditional techniques like Mass Spectrometry, these antibody arrays provide an interesting alternative for low abundance targets, with a sensitive and high throughput approach. tebu-bio laboratories has been appointed by RayBiotech as one of the 3 companies worldwide to perform contract research on these arrays, and can take your project on board from sample processing to data analysis. This post summarizes the services available, from protein profiling, to phosphorylation and glycosylation studies, including biostatistics support. It’s worth noting that all the arrays listed are compatible with most laser scanners and can be processed in any lab.

Continue reading
Supplying Discovery Tools

Want to know more about your Biologics?

13/09/2019 by Isabelle Nobiron, PhD No Comments

In new drug development pipelines, there is an increasing trend to switch from “small” to “large” molecules (also known as biologics). While the FDA guidance was quite specific with their recommendations for small molecules ADME-Tox studies, there is not much currently published for these large molecules.

The Japanese PDMA guidelines 2019 issue refers to some specificity regarding their internalization and degradation pathway. They are also well known to be prone to trigger cytokine release. The so called “cytokine storm” is one of the major toxicity events to be feared.

To support R&D projects around Biologics development, I have illustrated in this post what tebu-bio can offer in terms of reagents and services, including tools to monitor cytokine release (blood derivatives and cytokine multiplex assays), and reagents to help decipher their mechanism of action and catabolism.

Continue reading
Supplying Discovery Tools

Primary cells: ready-to-use, QC tested media

10/09/2019 by Isabelle Nobiron, PhD No Comments

In a previous post, I introduced a complete panel of ready-to-use specialized media for smooth muscle primary cells culture. Produced by Cell Applications, a GMP certified manufacturer of primary cells distributed by tebu-bio in Europe, these media were originally designed for Cell Applications own primary cells culture. However, many researchers isolating their own cells are using them to benefit from the expertise of a primary cell manufacturer and to use thoroughly QC tested media. Here, I invite you to look at a new selection for popular primary cell types, from skeletal muscle cells to synoviocytes, endothelial cells to pre-adipocytes. Have a read and find the one you need!

Continue reading
Page 12 of 213« First...10«11121314»203040...Last »

Most popular posts

  • HeLa cells: Origin of this important cell line in life science research
  • Monoclonal antibodies - all you need to know about antibody generation
  • How to choose the perfect buffer to get a pure, stabilised, functional protein
My Tweets

Privacy & Cookies: This site uses cookies. By continuing to use this website, you agree to their use.
To find out more, including how to control cookies, see here: Cookie Policy

Copyright © 2018 - tebu-bio - visit our main website at tebu-bio.com