Many initiatives led by worldwide scientific networks are currently being launched to decipher cellular mechanisms involved in SARS-CoV-2 cellular entry. For example, a recent study has identified 332 high confidence SARS-CoV-2-human protein-protein interactions (Gordon D.E. at al. “A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing” (March 2020) bioRxiv). All these efforts are aimed at rapidly discovering antiviral drugs with proven efficacy, and at developing vaccines to prevent COVID-19 outbreaks. This crisis also enables pharma & biotech companies to reposition their existing antiviral drugs (Harrison C. “Coronavirus puts drug repurposing on the fast track” (Feb. 2020), Nature). In this post, we’ll introduce new, recently released in vitro assays and SARS-CoV related chemical compounds to support COVID-19 early phase drug discovery projects.