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Acting and reacting in life science biotechnologies

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AIM Biochips – 3D cell culture platform for Immunotherapy and T Cell therapy studies

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As mentioned in a previous post  the DAX Biochips from AIM Biotech are an innovative and versatile microfluidic platform, allowing researchers to more easily develop 3D cell culture models, to work as close as possible to what occurs in the human body, but under in-vitro conditions.

Due to its innovative structure (as seen in this general AIM Chips flyer), a broad range of applications have already been validated on this model (Cellular Migration-Invasion Analysis / Angiogenesis studies / Metstasis Modeling System), but what’s new is that now Immunotherapy and T-Cell Therapy studies can be performed on this technology.

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New: Nipah Virus G Protein and antibodies for developing specific NiV ELISA test

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Nipah Virus Infection (NiV) is an emerging infectious disease of public health importance in the South-East Asia Region (source: World Health Organization). Along with Hendra virus (HeV), NiV is part of a new genus designated Henipavirus. Fruit bats have been identified as the natural reservoirs. Nevertheless, pigs, horses, goats, sheep, cats and dogs can also be infected and transmit the virus.

Symptoms of NiV infection are similar to influenza and in some cases can lead to encephalitis. The case fatality rate is high (40-70%) and there is no specific treatment. While able to bind with cellular EphrinB2, NiV G Protein (NiV-G) exhibits the antigenic epitopes and conformation necessary for specific antigen–antibody recognition. For this reason, Meridian Life Science have recently developed new Nipah virus glycoprotein (NiV-G) products suitable for the R&D projects of NiV using ELISA tests. [Read more…]

Find high performing monoclonal antibodies for your Renin-specific ELISA tests

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Released by the kidneys, Renin is an enzyme which belongs to the Renin-Angiotensin system (RAS) and is involved in blood pressure homeostasis.

In healthcare, Renin assay blood tests can be performed to find the cause of high blood pressure (hypertension). When tested alongside with Aldosterone measurements, one can obtain a complete understanding of an individual’s hormone balance.

Aldosterone Regulatory Hormone. Souce Arbor Assay

Aldosterone Regulatory Hormone Signalling pathway. Souce Arbor Assay

In preclinical and fundamental research, a Renin ELISA test therefore becomes of interest to monitor this biomarker in various disease states particularly when analyzed together with other biomarkers like Aldosterone and Cortisol. Different disorders can then be differentiated such as Primary and Secondary Hyperaldosteronism, Cushing syndrome, and Addison’s disease (adrenal insufficiency)… [Read more…]

Where to find antigens and antibodies for Enterovirus-specific Assay development

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Enteroviruses are common human viruses causing rather mild symptoms. However many different species and serotypes (incl. Echoviruses, Polioviruses, Coxsackieviruses A and B) can cause serious illness (like EV71 & Coxsackie A16 with Hand Foot and Mouth Disease or EV70 with acute haemorrhagic conjunctivitis, neurologic dysfunction and permanent polio-like paralysis).

In this brief post, you will discover recent Antigen & Antibody developments made in this field by Meridian Life Sciences.

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RayBiotech award tebu-bio as Best in Europe

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RayBiotech 2017 Outstanding Distributor Award - tebu-bio Best in Europe.

RayBiotech 2017 Outstanding Distributor Award – tebu-bio Best in Europe.

At the recent meeting of all RayBiotech distributors, Isabelle Nobiron PhD (Product Specialist, tebu-bio), was proud to receive the 2017 Outstanding Distributor Award – Best in Europe.

During this meeting, which took place in Guangzhou (China), RayBiotech (Norcross, USA) also appointed tebu-bio as one of the 3 centers in the world to perform contract research for their high density arrays. Up to 1000 human proteins, 200 mouse and 67 rat biomarkers can be tested on semi-quantitative or quantitative proteomics microarray platforms.

tebu-bio has been a longstanding, recognised RayBiotech Certified Services provider, performing outsourced immunoassays at their European Headquarters situated near Paris (full range of services tebu-bio services here).

RayBiotech, Inc. develop cutting edge proteomics tools for the advancement of basic and clinical research, and the facilitation of drug and biomarker discovery.  Their product-line covers 2,000+ rigorously tested ELISA tests (covered by a 90-day 100% satisfaction guarantee), Multiplex ELISA Arrays (Quantibody®), Membrane- or glass-slide Antibody Arrays (C-Series, G-Series, L-Series, E-Series), Functional assays, Research antibodies and Recombinant proteins.

tebu-bio provides their broad range of products to researchers across Europe. For more details, contact your local tebu-bio office.

 

Travel Grant Winners, where have they been to?

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tebu-bio’s latest Travel Grant draw took place on June 16th, and saw six more researchers win 400 Euros each towards attending the meeting of their choice.

Here’s some news from two of our previous winners (in October 2016 and February 2017), who were happy to share these pictures from the same meeting they both attended!

27th European Congress of Clinical Microbiology and Infectious Diseases – Vienna, Austria –  April 2017

Dr Giuliana Banche of the University of Torino (Italy) presenting her research.
Beatriz Rojo of the CIBIR (Spain), presenting her research.

Interested in winning 400 euros for your next meeting?

tebu-bio’s fourth and final draw for 2017 will take place in October, applications are now open and can be uploaded online here.

Sekisui XenoTech Awarded Cryopreservation Patent for Cryostax single freeze hepatocytes

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Sekisui XenoTech has just been issued U.S. Patent No. 9,642,355 for the “cryopreservation of cells and subcellular fractions,” specifically related to Sekisui XenoTech’s CryostaX® test systems. This hepatocyte cryopreservation method was invented by Maciej Czerwinski, Ph.D., Director of Consulting for Sekisui XenoTech. [Read more…]

AACR2017 Poster download – Modulation of CAF expressed podoplanin activity in TME

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This year again, we were pleased to attend the Annual meeting of the AACR (American Association for Cancer Research), which took place in Washington DC, USA at the beginning of April.

Nadia Normand Ph.D. (Business Development Manager, tebu-bio), presented a poster with results from collaborative work between the Centre for Molecular Biophysics of the CNRS (Orléans, France), tebu-bio Laboratories (Le Perray en Yvelines, France), Anaxomics Biotech (Barcelona, Spain) and the Institute of Immunology and Experimental Therapy (Wroclaw, Poland).

miRNome analyses reveal that activity of CAF expressed podoplanin in the tumor microenvironment is modulated by exosome miRNAs involved in the PTEN-PI3K-AKT-mTOR signaling
This poster “miRNome analyses reveal that activity of CAF expressed podoplanin in the tumor microenvironment is modulated by exosome miRNAs involved in the PTEN-PI3K-AKT-mTOR signaling” is now available for downloading – get your copy here.

New validated monoclonal antibody for Galectin-3 expression studies

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Galectin-3 (Mac-2) is a β-galactoside-binding lectin expressed in a variety of tissues and cell types (incl. activated macrophages, eosinophils, mast cells, dendritic cells, kidney cells, and sensory neurons).
Galectin-3 is a promiscuous protein modulating a diverse set of cellular functions such as cell adhesion, cell-matrix interactions, cell migration, macrophage activation, and apoptosis. [Read more…]