Alzheimer’s Disease (AD) is a type of dementia which induces progressive and non-reversible brain disorders (memory and cognitive loss, thinking and behavior changes…). AD ultimately ends in severe mental dysfunction due to neuronal death and breakdown of neural connections. The majority of people with AD are 65+ (late-onset AD). Even if age is one of the greatest risk factors, >5% of AD patients are in their 40s or 50s (early onset AD) making genes and heredityother important AD risk factors (1-4).
Mitochondria and their functional status provide an early indication of cellular toxicity and thus have emerged as a critical target in drug discovery and toxicity profiling. Apoptosis, necrosis and slow degenerative disease all exhibit changes in the electrochemical gradient across the mitochondrial membranes, ΔΨm, which give rise to the creation of the electronic potential necessary for ATP production.