Low oxygen tension, or Hypoxia, regulates numerous cellular and tissular functions.¬†In cancer research, hypoxia is a key regulator of tumor development, aggressiveness and therapy¬ resistance¬ by acting on malignant cells and their microenvironment. Hypoxia is also involved in¬†age-related diseases and¬†acts through intracellular and intercellular cascade of events¬ (exosomes, paracrine loops, angiogenesis…)¬ (1-2). [Read more…]
They¬ regulate gene expression by¬ interfering with the chromatin structure and the¬†binding of effector proteins to post-translational modified histones (1).
Several experimental strategies to analyze such binding have recently been designed; histone modified peptide arrays being one of them. [Read more…]
Resveratrol, a phenolic antioxidant with anti-ageing effects and properties in cancer therapy
Resveratrol (RSV) is a bioactive small molecule known to have antioxidant properties.¬†RSV¬†is a SIRT1 activator and ameliorates ageing-related phenotypes through cAMP phosphodiesterase inhibition. [Read more…]