Access to neural cellular models for in vitro Neuroscience research enters into a new era.

XCell Science, experts in cellular and genome engineering, provide genetically modified cellular models differentiated from Human induced Pluripotent Stem Cell (iPSC) lines. tebu-bio bring its scientific and logistics skills to deliver in Europe these high-quality and characterized neural cell derivatives for R&D, drug discovery, toxicology and regenerative medicine approaches.

Unlimited sources of biologically relevant functional neural cells

Proprietary high-efficiency protocols allow the directed differentiation of these iPS lines into a variety of functional neural cells, such as:

• Neural Stem Cells (NSC),
• Neurons,
• Dopaminergic neurons,
• Astrocytes.

Disease-specific knock-out isogenic neural cell lines

tebu-bio’s experts are pleased to introduce a collection of isogenic knock-out iPSC lines mimicking genetic defects identified in CNS disorders (Parkinson’s and Alzheimer’s diseases, Autism, Schizophrenia and Amyotrophic Lateral Sclerosis (ALS)):

• BDNF-/-: Homozygous knockout of the BDNF gene,
  

  Expression of TH in Ready-to-use XCell DOPA cells prolonged cultured in DOPA medium.

• APOE-/-: Homozygous knockout of the APOE gene,
• DISC1-/-: Homozygous knockout of the DISC1 gene,
• CNTNAP2-/-: Homozygous knockout of the CNTNAP2 gene,
• SOD1-/-: Homozygous knockout of the SOD1 gene,
• Park2-/-: Homozygous knockout of the Park2 gene,
• Park7-/-: Homozygous knockout of the Park7 gene.

Want to know more about these unlimited iPSC-derived neural cellular models ?

XCell Science by tebu-bio

Be among the first to receive the XCell Science launch pack by tebu-bio to optimise your in vitro CNS-specific cellular models.

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iPSC-derived Neural cells characterization – XCell Science by tebu-bio

Related posts regarding CNS and Stem cell studies:

• 3 unique Amyloid Beta peptide (Aß) research tools to boost Alzheimer’s Disease research
• 5 reasons to prefer the MOAB-2 antibody in Alzheimer‘s Disease research
• How is Amylo-Glo a brighter, longer lasting and higher definition Amyloid plaque marker?
• Return of SIRT1 deacetylase – Why is SIRT1 so attractive in Drug discovery and Stem cell research?
• 3 fluorogenic substrates for analyzing undifferentiated iPS and Stem cells
• Study how miRNAs regulate Stem cell homeostasis and differentiation

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