NF-κB (Nuclear Factor κ-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. Find the updated version of the NF-κB cell signaling pathway.

Collagen is a structural protein expressed in mammalian tissues (ex. skin, muscles, tendons, ligaments, cartilages, blood vessels…).  Together with Elastin and Keratin, Collagen fibres give connective properties to mammalial tissues ensuring their physiological form but also firmness, strength and flexibility. Needless to say, Collagen is trendy… a simple search in Google using the term “Collagen” clearly shows the economical dimension of this protein in well-being.

Ubiquitin (Ub) is an 8 kDa  highly conserved polypeptide, commonly expressed in eukaryotic cells. Ub is added to lysine residues of the target proteins. This post-translational modification (known as ubiquitination) is made through the sequential action of 3 enzymes (E1 Ub activating enzyme, E2 conjugating enzyme and E3 ligase).

Histone-lysine N-methyltransferase EZH2  is a methyltransferase involved in transcriptional gene regulation. Together with with EED, RbAP48, SUZ12 and AEBP2, EZH2 forms a 5-member complex that adds 3 methyl groups to Lysine 27 of Histone H3 (H3K27). EZH2 acts on chromatin condensation and gene transcription activity.