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  • Home
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    • ADME-Tox
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Cell Biology and Signalling, Drug Discovery, Headlines, Supplying Discovery Tools

A 96-well Invasion Assay Compatible with High Content Screening

09/04/2014 by Jean-François Têtu, PhD No Comments

The transition from non-invasive phenotype to invasive phenotype of tumor cells marks the switch from a benign tumor to a more malignant form of cancer. Understanding the mechanisms underlying this hallmark event, which enables tumor cells to invade through Extracellular matrix, is critical for discovering pathways and new targets to develop anti-metastatic strategies. The discovery of anti-metastatic agents that inhibit cancer cell motility has been hindered by a dearth of cell motility assays that are compatible with high–throughput screening.

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Drug Discovery

Histone Peptide Arrays' contribution in Epigenetic studies

12/03/2014 by Philippe Fixe, PhD No Comments
EpiGold™ Histone Peptide Array Data-ECL

EpiGold™ Histone Peptide Array Data-FluorescenceDNA methylation and histone post-translational modifications are key epigenetic factors.

They regulate gene expression by interfering with the chromatin structure and the binding of effector proteins to post-translational modified histones (1).

Several experimental strategies to analyze such binding have recently been designed; histone modified peptide arrays being one of them.

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