• Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
  • Facebook
  • LinkedIn
  • Twitter
  • YouTube
Home
Research areas
    ADME-Tox
    Biomarkers
    Cell Biology and Signalling
    Cell Sourcing - Cell Culture Technologies
    Drug Discovery
    Gene Expression - Molecular Biology
    Stem Cells
    Supplying Discovery Tools
Contact us
Meet the authors
tebu-bio's blog - Acting and reacting in life sciences and biotechnologies
  • Home
  • Research areas
    • ADME-Tox
    • Biomarkers
    • Cell Biology and Signalling
    • Cell Sourcing – Cell Culture Technologies
    • Drug Discovery
    • Gene Expression – Molecular Biology
    • Stem Cells
    • Supplying Discovery Tools
  • Contact us
  • Meet the authors
Drug Discovery

Ion channel over expressing cell lines for inhibitory screening

18/09/2015 by Ali El Baya, PhD 2 Comments
TRPV1 ion channel. Brauchi S et al. (2007).

In a recent post on  Venomous toxin ion channel modulators, we looked at toxin derived peptides to manipulate a wide variety of ion channels. These toxins can be used as tools to characterize specific ion channels, but they can also be utilized as reference inhibitors in ion channel drug screening campaigns.

Today, let’s take a look at cell lines over expressing specific ion channels and designed for cell based ion channel assays in drug discovery.

Continue reading
Drug Discovery

Venomous toxin ion channel modulators

04/09/2015 by Ali El Baya, PhD No Comments
Synthetic active peptides derived from snake

Ion channels are proteins with pore-forming abilities. Their selective capabilities to let ions cross the cell membrane involves them in crucial cellular functions (controlling membrance potential, the flow of ions, regulating cell volume). Ion channels are involved in the patho-physiology of so many diseases, they are natural candidates for pharma R&D programs. We will review here a series of highly selective ion channel modulators which are ideal for performing drug discovery screenings.

Continue reading
Drug Discovery

Mambalgin 1 – Blocking ASIC channels in pain pathways

20/07/2015 by Ali El Baya, PhD No Comments
Synthetic active peptides derived from snake

Acid-Sensing Ion Channels (ASICs) are neuronal voltage-insensitive cationic channels which are activated by extracellular protons. They belong to the ENaC/Deg superfamily of ion channels. Up to now 6 members of the ASIC family have been identified: ASIC1 – ASIC 4, and the splice variants ASIC1a, 1b and 2a, 2b. The ASIC family members are trimeric and can be made up of different combinations of subunits. All ASICs are expressed in the peripheral nervous system. ASIC1a, 2a, 2b and 4 are expressed in the central nervous system. ASICs are promising drug targets for treating a wide variety of conditions linked to both the CNS and PNS especially implied in pain pathways.

Continue reading
Drug Discovery

Keen to work with the best quality nucleosomes?

17/07/2015 by Ali El Baya, PhD No Comments
Histone Structure- tebu-bio

Fig. 1: Structure of a mono-nucleosome.

Nucleosomes are basis units of DNA packaging in eukaryotic cells. A core particle (mono-nucleosome) consists of a segment of DNA called core DNA (147 bp in length) wound around a histone octamer (Fig 1.). Histone octamers are made up of 2 copies of the the core histones H2A, H2B, H3, and H4. These mono-nucleosomes are connected by linker 80bp-long DNA. H1 histone, the so-called linker histone, binds to the linker DNA close to the entry and exit of the core DNA and is involved in chromatin compaction (Fig 1.).

Continue reading
Page 10 of 22« First...«9101112»20...Last »
tebu-bio

LAB SERVICES OUTSOURCING

• Protein production

• Plasmid Preps

• 3D Cell Culture
LEARN MORE

Top contributors

Dimitri Szymczak, PhD
Dimitri Szymczak, PhD
  • Adenovirus-based KO
  • New – you know CRISPR, now it’s Prime Editing
Frédéric Samazan
Frédéric Samazan
  • Five new fluorescent probes to easily image live cellular processes
  • Immuno-Oncology: 6 must-haves to boost your projects
Isabelle Nobiron, PhD
Isabelle Nobiron, PhD
  • Accelerate your Biomarker discovery with High Density arrays
  • Want to know more about your Biologics?
Isabelle Topin, PhD
Isabelle Topin, PhD
  • Antibody Purification: Tips and Tricks
  • Monoclonal antibodies – all you need to know about antibody generation
Philippe Fixe, PhD
Philippe Fixe, PhD
  • ChIP for sensitive & fast genomic mapping
  • Recent developments in 3D cell culture hydrogel

Copyright © 2018 - tebu-bio - visit our main website at tebu-bio.com