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3D cell culture Biochip – versatile for more physiological applications

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By mimicking in-vivo environments, 3D cell culture models appear nowadays as the best in-vitro study model to work in an in-vivo like study model and to obtain more physiologically relevant data and proof of concept as close as possible to “a clinical context”.

3D cell culture chip - AIM Biotech

3D cell culture chip – AIM Biotech

To accompany researchers along this way, there are several innovative cell culture devices (available in Europe through tebu-bio), and more specifically a modular microfluidic platform for 3D cell culture with the capability to monitor complex biological systems dynamics in response to tuned microenvironment: the 3D Cell culture chip (Aim Biotech) [Read more…]

Pluripotent stem cells for improved reprogrammed Human Sebocytes

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Following the start of our recent collaboration with Phenocell, we’re pleased to be able to provide high quality Sebocytes developed from Human induced pluripotent stem cells (iPSC). Thanks to a perfectly standardized reprogramming protocol, they display lower batch to batch variability, allowing better reproducibility and accuracy of your experimental results. [Read more…]

Microcell arrays – obtain more accurate data from single living cells

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Understanding how mammalian cells function requires a dynamic perspective. Recent improvements in our abilities to perform fluorescence microscopy on primary cells, coupled with advances in pipelines for quantifying and extracting data, have made possible a better understanding of the temporal complexity of cell signalling pathway. Due to the heterogeneity seen in both eukaryotic and prokaryotic cell populations, study at the single cell resolution with living cells is currently the best solution to understand the dynamics between environmental conditions and cellular behaviour.

However as living cells don’t stay still, classical imaging and studying methods present some drawbacks for single cell analysis and tracking such as: [Read more…]

3D Cell culture: Innovative cell culture devices for more predictive 3D models

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One of the biggest challenges as a researcher in life sciences, is to obtain proof of concept the more predictive as possible. To help you to reach your objectives, many innovative tools are being developed and new techniques are emerging. In this post, I’d like to essentially focus on two innovative cell culture devices which mimic in-vivo conditions in in-vitro systems, in fields such as 3D cell culture, Microfluidics and oriented cell culture. [Read more…]

CTLA-4 discovery in dendritic cells – a new role in Cancer Immunotherapy?

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New research suggests that dendritic cells produce and release CTLA-4, which typically inhibits anticancer responses.

Cancer immunotherapy strategies have made it increasingly evident that the immune system plays an integral role in managing and destroying cancer. Nevertheless, many mechanisms of immune suppression exist that may inhibit antitumour immunity. Recently, strategies that implement antibodies directed against negative immunologic regulators have demonstrated significant success. Cytotoxic T-lymphocyte-associate protein-4 (CTLA-4) was the first immunologic checkpoint to be clinically targeted, by the cancer immunotherapeutic ipilimumab, an FDA-approved drug to treat melanoma. After T-cell activation, CTLA-4 is upregulated on the cell surface where it functions to downregulate T cell function. Ipilimumab binds to CTLA-4 on T cells, which blocks the inhibitory signals and enhances anti-cancer immune responses.

[Read more…]

Align your cells with nanoscale topography cell cultureware

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NanoSurface Biomedical’s ANFS (Anisotropically NanoFabricated Substratum) technology brings an in vivo-like cell culture platform to researchers for in vitro cell/tissue studies.Align your cells - NanoSurface Biomedical at tebu-bio

Featuring topographical resemblance to the extracellular matrix, these nanopatterned substrates provide a topographical and mechanical niche for cells to grow as if they are in vivo.

The nanopatterned surfaces influence both cellular morphology and phenotype.

For example, when used with cardiomyocytes, one can observe formation of striated sarcomeres, intercalated discs, and polarized expression of gap junction proteins such as Connexin 43 (Cx43).

Phenotypically, cells cultured on ANFS are more mature, and more physiological, so that your studies are more predictive.

[Read more…]

How to choose the best 3D technology for your assay?

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Cell culture models using 2D substrates have provided important conceptual advances in understanding the biology of cells. However, cells grown on flat 2D surfaces can differ substantially from physiological environments. Animal models provide a useful tool to study biology in a physiologically relevant environment. However, animals models are expensive, time-consuming, use a significant amount of test material, and do not always provide a useful extrapolation to humans. In vitro 3D cell culture models bridge the gap between the two, allowing the study of human cells in a physiologically-relevant environment with the convenience and speed of an in vitro model. [Read more…]

“Extraordinary” CAR T Cells eliminate cancer after stem cell transplant

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Donor-derived lymphocytes attack a patient’s cancer — but may attack the patient as well. Donor chimeric antigen receptor (CAR) T cells, on the other hand, brought remissions without this troubling complication.

CAR T cells continue to make waves: At the latest annual meeting of the American Association for the Advancement of Science, it was announced that CAR T cells, in which T cells from a patient are genetically reprogrammed to target cancer cells, removed all traces of cancer in the bone marrow of 27 out of 29 acute lymphoblastic leukemia patients. Nineteen of 30 individuals with non-Hodgkin lymphoma also responded in the form of partial or complete responses. The cumulative successes found in CAR T cell studies have labeled them “extraordinary.”[1] [Read more…]